Evidence map›Paper›PMID 27896952›Full record

Trial reportJournal of cachexia, sarcopenia and muscle2017

Muscle strength in breast cancer patients receiving different treatment regimes.

Oliver Klassen, Martina E Schmidt, Cornelia M Ulrich, Andreas Schneeweiss, Karin Potthoff, Karen Steindorf, Joachim Wiskemann

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cachexia, sarcopenia and muscle, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06540612 (Effects of Aerobic Exercise on Cancer-Related Biomarkers, Functional Capacity, Cognitive Status and Quality of Life in Women With Breast Cancer), which is not on this map. Cited by 106 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 7 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06540612 nacompletednot on this mapstarted 2024, after this paper: background citation

Effects of Aerobic Exercise on Cancer-Related Biomarkers, Functional Capacity, Cognitive Status and Quality of Life in Women With Breast Cancer

TypeinterventionalSponsorHasan Kalyoncu UniversityRan2024 to 2026Enrolled69ConditionsBreast Cancer Female, Quality of Life, SurvivorshipArmsAerobic exercise, Physical activity counseling
3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 7 syntheses or guidelines pooled it, 231 citations in OpenAlex.

  1. Impact of resistance training on fatigue among breast cancer patients undergoing chemotherapy: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  2. Effects of resistance training on quality of life, fatigue, physical function, and muscular strength during chemotherapy treatment: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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  11. Effects of Tai Chi Chuan on physical function and health in breast cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  12. Variability in resistance training trajectories of breast cancer patients undergoing therapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Oliver KlassenDivision of Sports Therapy, Hospital Münsterland, Bad Rothenfelde, Germany.
Martina E SchmidtDivision of Physical Activity, Prevention and Cancer, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Cornelia M UlrichHuntsman Cancer Center, Salt Lake City, USA.
Andreas SchneeweissDivision of Gynecological Oncology, National Center for Tumor Diseases (NCT) and University Hospital, Heidelberg, Germany.
Karin PotthoffDivision of Medical Oncology, National Center for Tumor Diseases (NCT) and University Hospital, Heidelberg, Germany.
Karen SteindorfDivision of Physical Activity, Prevention and Cancer, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Joachim WiskemannDivision of Medical Oncology, National Center for Tumor Diseases (NCT) and University Hospital, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-5971-5436
German Cancer Research Center · DEHeidelberg University · DEHuntsman (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMuscle dysfunction and sarcopenia have been associated with poor performance status, an increased mortality risk, and greater side effects in oncologic patients. However, little is known about how performance is affected by cancer therapy. We investigated muscle strength in breast cancer patients in different adjuvant treatment settings and also compared it with data from healthy individuals.

methodsBreast cancer patients (N = 255) from two randomized controlled exercise trials, staged 0-III and aged 54.4 ± 9.4 years, were categorized into four groups according to their treatment status. In a cross-sectional design, muscle function was assessed bilaterally by isokinetic dynamometry (0°, 60°, 180°/s) as maximal voluntary isometric contraction (MVIC) and maximal isokinetic peak torque (MIPT) in shoulder rotators and knee flexors and extensors. Additionally, muscular fatigue index (FI%) and shoulder flexibility were evaluated. Healthy women (N = 26), aged 53.3 ± 9.8 years, were tested using the same method. Analysis of covariance was used to estimate the impact of different cancer treatments on skeletal muscle function with adjustment for various clinical and socio-demographic factors.

resultsConsistently, lower muscle strength was measured in shoulder and knee strength in patients after chemotherapy. On average, patients had up to 25% lower strength in lower extremities and 12-16% in upper extremities in MVIC and MIPT during cancer treatment compared with healthy women. No substantial difference between patient groups in shoulder strength, but significantly lower shoulder flexibility in patients with radical mastectomy was measured. Chemotherapy-treated patients had consistently higher FI%. No serious adverse events were reported.

conclusionsBreast cancer patients showed markedly impaired muscle strength and joint dysfunctions before and after anticancer treatment. The significant differences between patients and healthy individuals underline the need of exercise therapy as early as possible in order to prevent or counteract the loss of muscle function after curative surgery as well as the consequences of neo-/adjuvant chemotherapy.

Indexed as

Breast NeoplasmsChemotherapy, AdjuvantMuscle StrengthRadiotherapy, AdjuvantAdultFemaleHumansKneeMiddle AgedMuscle ContractionMuscle FatigueMuscle, SkeletalResistance TrainingShoulderTorqueChemotherapyIsokineticIsometricMulti-jointMuscle function

Identifiers

PMID27896952
PMCPMC5377413
OpenAlexW2557299371

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.