Evidence map›Paper›PMID 27896942›Full record

ArticleAutism research : official journal of the International Society for Autism Research2017

Mid-childhood outcomes of infant siblings at familial high-risk of autism spectrum disorder.

Elizabeth Shephard, Bosiljka Milosavljevic, Greg Pasco, Emily J H Jones, Teodora Gliga, Francesca Happé, Mark H Johnson, Tony Charman, BASIS Team

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autism research : official journal of the International Society for Autism Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  13. Mid-childhood autism sibling recurrence in infants with a family history of autism.Autism research : official journal of the International Society for Autism Research · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Elizabeth ShephardMRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, & Neuroscience, King's College London, London, UK.
Bosiljka MilosavljevicDepartment of Psychology, Institute of Psychiatry, Psychology, & Neuroscience, King's College London, London, UK.
Greg PascoDepartment of Psychology, Institute of Psychiatry, Psychology, & Neuroscience, King's College London, London, UK.
Emily J H JonesCentre for Brain and Cognitive Development, School of Psychology, Birkbeck College, London, UK.ORCID http://orcid.org/0000-0001-5747-9540
Teodora GligaCentre for Brain and Cognitive Development, School of Psychology, Birkbeck College, London, UK.
Francesca HappéMRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology, & Neuroscience, King's College London, London, UK.
Mark H JohnsonCentre for Brain and Cognitive Development, School of Psychology, Birkbeck College, London, UK.
Tony CharmanDepartment of Psychology, Institute of Psychiatry, Psychology, & Neuroscience, King's College London, London, UK.
BASIS Team

Funding

Medical Research Council G0701484Medical Research Council G9817803Medical Research Council MR/K021389/1
6 · The paper itself

Abstract

Almost 20% of infants with an older sibling with autism spectrum disorder (ASD) exhibit ASD themselves by age 3 years. The longer-term outcomes of high-risk infants are less clear. We examined symptoms of ASD, attention-deficit/hyperactivity disorder (ADHD) and anxiety, language, IQ, and adaptive behaviour at age 7 years in high- and low-risk children prospectively studied since the first year of life. Clinical outcomes were compared between high-risk children who met diagnostic criteria for ASD at age 7 (HR-ASD-7 group, n = 15), high-risk children without ASD (HR-Non-ASD-7 group, n = 24), and low-risk control children (LR group, n = 37). Diagnostic stability between age 3 and 7 years was moderate, with five children who did not meet diagnostic criteria for ASD at age 3 years being assigned the diagnosis at age 7, and three children showing the opposite pattern. The HR-ASD-7 group showed elevated ADHD and anxiety symptoms and had lower adaptive behaviour scores than LR controls. The HR-Non-ASD-7 group had higher repetitive behaviour, lower adaptive functioning and elevated scores on one anxiety subscale (Separation Anxiety) compared to LR controls, but evidence for subclinical ASD symptoms (the broader autism phenotype, BAP) was limited in the group as a whole, although we identified a subgroup with elevated ASD traits. The difficulties experienced by high-risk siblings at school-age extend beyond ASD symptoms. The pattern of difficulties exhibited by the HR-ASD-7 group may inform our understanding of developmental trajectories of co-occurring psychopathology in ASD. Autism Res 2017, 10: 546-557. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.

Indexed as

SiblingsAutism Spectrum DisorderChildChild, PreschoolCohort StudiesFemaleHumansInfantMalePhenotypeRiskSex FactorsUnited KingdomADHDanxietybroader autism phenotypeclinical outcomeshigh-risk siblings

Identifiers

PMID27896942
PMCPMC5408391

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.