ArticleJournal of diabetes2017
Increased identification of novel variants in type 2 diabetes, birth weight and their pleiotropic loci.
Article in Journal of diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Linking Alzheimer's disease and type 2 diabetes: Novel shared susceptibility genes detected by cFDR approach.Journal of the neurological sciences · 2017Pooled it
- Exploring the novel SNPs in neuroticism and birth weight based on GWAS datasets.BMC medical genomics · 2023Article
- Identification of novel functional CpG-SNPs associated with Type 2 diabetes and birth weight.Aging · 2021Article
- Enhanced Identification of Novel Potential Variants for Appendicular Lean Mass by Leveraging Pleiotropy With Bone Mineral Density.Frontiers in immunology · 2021Article
- Article
- Identification of novel functional CpG-SNPs associated with type 2 diabetes and coronary artery disease.Molecular genetics and genomics : MGG · 2020Article
- Article
- Improved detection of common variants in coronary artery disease and blood pressure using a pleiotropy cFDR method.Scientific reports · 2019Article
- Identification of novel genetic variants for type 2 diabetes, childhood obesity, and their pleiotropic loci.Journal of human genetics · 2019Article
- Regulation of in vivo dynein force production by CDK5 and 14-3-3ε and KIAA0528.Nature communications · 2019Article
- Additional common variants associated with type 2 diabetes and coronary artery disease detected using a pleiotropic cFDR method.Journal of diabetes and its complications · 2018Article
- Article
- Identifying potentially common genes between dyslipidemia and osteoporosis using novel analytical approaches.Molecular genetics and genomics : MGG · 2018Article
- Estimating and testing direct genetic effects in directed acyclic graphs using estimating equations.Genetic epidemiology · 2018Article
- Improved detection of genetic loci in estimated glomerular filtration rate and type 2 diabetes using a pleiotropic cFDR method.Molecular genetics and genomics : MGG · 2018Article
- Identification of Novel Potentially Pleiotropic Variants Associated With Osteoporosis and Obesity Using the cFDR Method.The Journal of clinical endocrinology and metabolism · 2018Article
- Novel Common Variants Associated with Obesity and Type 2 Diabetes Detected Using a cFDR Method.Scientific reports · 2017Article
- Novel common variants associated with body mass index and coronary artery disease detected using a pleiotropic cFDR method.Journal of molecular and cellular cardiology · 2017Article
- Article
- Identification of novel genetic loci for osteoporosis and/or rheumatoid arthritis using cFDR approach.PloS one · 2017Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundClinical and epidemiological findings point to an association between type 2 diabetes (T2D) and low birth weight. However, the nature of the relationship is largely unknown. The aim of this study was to identify novel single nucleotide polymorphisms (SNPs) in T2D and birth weight, and their pleiotropic loci.
methodsA pleiotropy-informed conditional false discovery rate (cFDR) method was applied to two independent genome-wide association studies (GWAS) summary statistics of T2D (n = 149 821) and birth weight (n = 26 836).
resultsA conditional Q-Q plot showed strong enrichment of genetic variants in T2D conditioned on different levels of association with birth weight. 133 T2D-associated SNPs, including 120 novel SNPs, were identified with a significance threshold of cFDR < 0.05; 13 significant birth weight-associated SNPs, including 12 novel SNPs (cFDR < 0.05) were identified. Conjunctional cFDR (ccFDR) analysis identified nine pleiotropic loci, including seven novel loci, shared by both T2D and birth weight (ccFDR < 0.05). Two novel SNPs located at the CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1; rs1012635; cFDR < 0.05) and adenylate cyclase 5 (ADCY5; rs4677887; cFDR < 0.05) genes are of note. These two genes increase the risk of T2D and low birth weight through the pathway of the "fetal insulin hypothesis."
conclusionSeveral pleiotropic loci were identified between T2D and birth weight by leveraging GWAS results. The results make it possible to explain a greater proportion of trait heritability and improve our understanding of the shared pathophysiology between T2D and birth weight.
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