Evidence map›Paper›PMID 27896656›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2017

Pancreatitis After Pancreatoduodenectomy Predicts Clinically Relevant Postoperative Pancreatic Fistula.

C M Kühlbrey, N Samiei, O Sick, F Makowiec, U T Hopt, U A Wittel

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Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
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  15. Post-Pancreatectomy Acute Pancreatitis-The New Criteria Fail to Recognize Significant Presentations.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

C M KühlbreyClinic for General and Visceral Surgery, Department of Surgery, University of Freiburg, Freiburg, Germany.
N SamieiClinic for General and Visceral Surgery, Department of Surgery, University of Freiburg, Freiburg, Germany.
O SickClinic for General and Visceral Surgery, Department of Surgery, University of Freiburg, Freiburg, Germany.
F MakowiecClinic for General and Visceral Surgery, Department of Surgery, University of Freiburg, Freiburg, Germany.
U T HoptClinic for General and Visceral Surgery, Department of Surgery, University of Freiburg, Freiburg, Germany.
U A WittelClinic for General and Visceral Surgery, Department of Surgery, University of Freiburg, Freiburg, Germany. uwe.wittel@uniklinik-freiburg.de.
University of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMorbidity after pancreas resection is still high with postoperative pancreatic fistulas (POPF) being the most frequent complication. However, exocrine insufficiency seems to protect from POPF. In clinical practice, patients showing increased postoperative systemic amylase concentrations appear to frequently develop POPF. We therefore retrospectively examined the occurrence of systemic amylase increase after pancreas resections and its association with the clinical course. PATIENTS AND

methodsPerioperative data from 739 consecutive pancreas resections were assessed in a prospectively maintained SPSS database. Serum and drain amylase concentrations were determined by routine clinical chemistry. POPFs were graded into A-C according to ISGPF definitions.

resultsIn patients with reduced serum amylase (n = 89) on day 1 after pancreatoduodenectomy, clinically relevant POPFs were not observed. In patients with normal serum amylase concentrations, clinically relevant POPFs occurred in 9 %, while in 39 % of the patients with more than three times elevated amylase concentrations, a clinically relevant postoperative fistula was observed (p < 0.001). Systemic hyperamylasemia detected on postoperative day 1 after pancreatoduodenectomy was further a good predictor for clinically relevant POPFs (AUROC = 0.797, p < 0.001).

conclusionPatients with a high risk for developing clinically relevant POPFs can be identified on the first postoperative day by determining serum amylase.

Indexed as

AdolescentAdultAgedAged, 80 and overAmylasesDrainageFemaleHumansMaleMiddle AgedPancreatic FistulaPancreaticoduodenectomyPancreatitisPostoperative ComplicationsRetrospective StudiesRisk FactorsAmylasesDistal pancreatectomyPancreatic fistulaPancreatoduodenectomyPostoperative pancreatitis

Identifiers

PMID27896656
OpenAlexW2558414567

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.