Evidence map›Paper›PMID 27896597›Full record

ArticleThe journal of physiological sciences : JPS2017

Noradrenergic inhibition of spinal hyperexcitation elicited by cutaneous cold stimuli in rats with oxaliplatin-induced allodynia: electrophysiological and behavioral assessments.

Seunghwan Choi, Akihiro Yamada, Woojin Kim, Sun Kwang Kim, Hidemasa Furue

Open access · goldAbstract read
In one paragraph

Article in The journal of physiological sciences : JPS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Seunghwan ChoiDepartment of Physiology, College of Korean Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea.
Akihiro YamadaDepartment of Information Physiology, National Institute for Physiological Sciences, Okazaki, 444-8787, Japan.
Woojin KimDepartment of Physiology, College of Korean Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea.
Sun Kwang KimDepartment of Physiology, College of Korean Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea. skkim77@khu.ac.kr.ORCID http://orcid.org/0000-0002-2649-6652
Hidemasa FurueDepartment of Information Physiology, National Institute for Physiological Sciences, Okazaki, 444-8787, Japan. furue@nips.ac.jp.
Kyung Hee University · KRNational Institute for Physiological Sciences · JPThe Graduate University for Advanced Studies, SOKENDAI · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the spinal action of noradrenaline on cold-elicited hyperexcitation detected in dorsal horn neurons of rats with allodynia induced by an oxaliplatin (6 mg/kg, i.p.) injection. In vivo extracellular recordings from the spinal dorsal horn showed that wide dynamic range neurons responded to cutaneous acetone (10 μl) stimulation in normal rats, and cold-elicited firings in oxaliplatin-administered rats were increased with a longer duration, correlated with behavioral responses. These responses were significantly attenuated by spinal administration (50 μM) of noradrenaline or its agonists, clonidine (α

Indexed as

AnimalsCold TemperatureElectrophysiological PhenomenaHyperalgesiaMaleNorepinephrineOrganoplatinum CompoundsOxaliplatinRatsRats, Sprague-DawleySpinal Cord Dorsal HornNorepinephrineOrganoplatinum CompoundsOxaliplatinCold allodyniaIn vivo extracellular recordingNoradrenalineOxaliplatinSpinal cordWide dynamic range neurons

Identifiers

PMID27896597
PMCPMC10718019
OpenAlexW2559442997

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.