ArticleWorld journal of microbiology & biotechnology2017
Highly improved acarbose production of Actinomyces through the combination of ARTP and penicillin susceptible mutant screening.
Article in World journal of microbiology & biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Multi-level metabolic engineering for squalene production: from pathway optimization to systematic regulation.World journal of microbiology & biotechnology · 2026Review
- Improving fidaxomicin production through ARTP mutagenesis and fermentation optimization inSynthetic and systems biotechnology · 2025Article
- Enhancement of Acarbose Production inJournal of agricultural and food chemistry · 2025Article
- Improved Natamycin Production inMicroorganisms · 2025Article
- Application of Atmospheric and Room-Temperature Plasma (ARTP) to Microbial Breeding.Current issues in molecular biology · 2023Review
- Integration of ARTP Mutation and Adaptive Laboratory Evolution to Reveal 1,4-Butanediol Degradation in Pseudomonas putida KT2440.Microbiology spectrum · 2023Article
- Enhancing wuyiencin productivity of Streptomyces albulus (CK15) by mutagenesis breeding with atmospheric and room temperature plasma.World journal of microbiology & biotechnology · 2023Article
- Breeding of New Strains of Gracilariopsis lemaneiformis with High Agar Content by ARTP Mutagenesis and High Osmotic Pressure Screening.Marine biotechnology (New York, N.Y.) · 2023Article
- Avilamycin production enhancement by mutagenesis and fermentation optimization in Streptomyces viridochromogenes.World journal of microbiology & biotechnology · 2022Article
- Multi-omics Comparative Analysis ofFrontiers in microbiology · 2020Article
- Article
- Effects of Atmospheric and Room Temperature Plasma (ARTP) Mutagenesis on Physicochemical Characteristics and Immune Activity In Vitro of Hericium erinaceus Polysaccharides.Molecules (Basel, Switzerland) · 2019Article
- Combinatorial Effect of ARTP Mutagenesis and Ribosome Engineering on an Industrial Strain ofFrontiers in bioengineering and biotechnology · 2019Article
- Enhancing transglutaminase production ofBioresources and bioprocessing · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atmospheric and room temperature plasma (ARTP) was first employed to generate mutants of Actinomyces JN537 for improving acarbose production. To obtain higher acarbose producing strains, the method of screening the strains for susceptibility to penicillin was used after treatment with ARTP. The rationale for the strategy was that mutants showing penicillin susceptibility were likely to be high acarbose producers, as their ability to synthesize cell walls was weak which might enhance metabolic flux to the pathway of acarbose biosynthesis. Acarbose yield of the mutant strain M37 increased by 62.5 % than that of the original strain. The contents of monosaccharides and amino acids of the cell wall of M37 were lower than that of the original strain. The acarbose production ability in mutant strain remained relatively stable after 10 generations. This work provides a promising strategy for obtaining high acarbose-yield strains by combination of ARTP mutation method and efficient screening technique.
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