ArticlePituitary2017
Anti-pituitary antibodies against corticotrophs in IgG4-related hypophysitis.
Article in Pituitary, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Progress and Challenges of Immune Checkpoint Inhibitor-Induced Hypophysitis.Journal of clinical medicine · 2023Review
- Anti-tumor effects of anti-programmed cell death-1 antibody treatment are attenuated in streptozotocin-induced diabetic mice.Scientific reports · 2023Article
- IgG4-related hypophysitis: a retrospective cohort study.Acta neurochirurgica · 2022Article
- Studies on anti-rabphilin-3A antibodies in 15 consecutive patients presenting with central diabetes insipidus at a single referral center.Scientific reports · 2022Article
- Sellar germinoma mimicking IgG4-related hypophysitis: a case report.BMC endocrine disorders · 2022Article
- Markers of humoral and cell-mediated immune response in primary autoimmune hypophysitis: a pilot study.Endocrine · 2021Article
- Anti-pituitary antibodies and susceptible human leukocyte antigen alleles as predictive biomarkers for pituitary dysfunction induced by immune checkpoint inhibitors.Journal for immunotherapy of cancer · 2021Article
- Clinical Characteristics, Management, and Potential Biomarkers of Endocrine Dysfunction Induced by Immune Checkpoint Inhibitors.Endocrinology and metabolism (Seoul, Korea) · 2021Review
- Disease heterogeneity in IgG4-related hypophysitis: report of two histopathologically proven cases and review of the literature.Virchows Archiv : an international journal of pathology · 2019Review
- The Immunologic Paradoxes of IgG4-Related Disease.Clinical reviews in allergy & immunology · 2018Review
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Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIgG4-related disease is a systemic inflammatory disease characterized by infiltration of IgG4-positive plasma cells into multiple organs, including the pituitary gland. Autoimmunity is thought to be involved in the pathogenesis of IgG4-related disease. The diagnosis of IgG4-related hypophysitis (IgG4-RH) is difficult because its clinical features, such as pituitary swelling and hypopituitarism, are similar to those of other pituitary diseases, including lymphocytic hypophysitis and sellar/suprasellar tumors. The presence and significance of anti-pituitary antibodies (APA) in IgG4-RH is unclear.
methodsIn this case-control study, we used single indirect immunofluorescence on human pituitary substrates to assess the prevalence of serum APA in 17 patients with IgG4-RH, 8 control patients with other pituitary diseases (lymphocytic infundibulo-neurohypophysitis, 3; craniopharyngioma, 2; germinoma, 3), and 9 healthy subjects. We further analyzed the endocrine cells targeted by the antibodies using double indirect immunofluorescence.
resultsAPA were found in 5 of 17 patients with IgG4-RH (29%), and in none of the pituitary controls or healthy subjects. The endocrine cells targeted by the antibodies in the 5 IgG4-RH cases were exclusively corticotrophs. Antibodies were of the IgG1 subclass, rather than IgG4, in all 5 cases, suggesting that IgG4 is not directly involved in the pathogenesis. Finally, antibodies recognized pro-opiomelanocortin in 2 of the cases.
conclusionsOur study suggests that autoimmunity is involved in the pathogenesis of IgG4-RH and that corticotrophs are the main antigenic target, highlighting a possible new diagnostic marker for this condition.
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