ArticleCytotechnology2017
Cytotoxic and apoptotic activities of extract of Amaranthus spinosus L. in Allium cepa and human erythrocytes.
Article in Cytotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 35 citations in OpenAlex.
- Alleviatory efficacy of achillea millefolium L. in etoxazole-mediated toxicity in allium cepa L.Scientific reports · 2024Article
- Regulating Enzyme Catalysis by Tailored Silver Nanocrystals Fabricated with Holigarna arnottiana-Synthesis, Characterization, and Performance Optimization.Biological trace element research · 2024Article
- Genotoxic effects induced by iprodione and tebuconazole in meristematic cells of Allium cepa: responses dependent on concentration and exposure time.Environmental science and pollution research international · 2024Article
- Effects of modified sediments on the growth of submerged macrophyteFrontiers in plant science · 2024Article
- Salinity Stress Ameliorates Pigments, Minerals, Polyphenolic Profiles, and Antiradical Capacity in Lalshak.Antioxidants (Basel, Switzerland) · 2023Article
- Colorant Pigments, Nutrients, Bioactive Components, and Antiradical Potential of Danta Leaves (Antioxidants (Basel, Switzerland) · 2022Article
- Phytonutrients, Colorant Pigments, Phytochemicals, and Antioxidant Potential of Orphan LeafyMolecules (Basel, Switzerland) · 2022Article
- Toxicological study of aqueous-methanol solvent fraction of methanol extract ofToxicology reports · 2020Article
- Cytotoxic and apoptotic effects of root extract and tanshinones isolated fromIranian journal of basic medical sciences · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study examined the apoptosis inducing effects of Amaranthus spinosus L. aqueous extract in Allium cepa root meristematic cells and human erythrocytes. Cytogenetic assay revealed many apoptosis inducing cytogenetic aberrations viz., cytoplasmic breakage, cytoplasmic disintegration, cytoplasmic shrinkage, receding of cytoplasm, cytoplasmic vacuolation, enucleated cell, ghost cell, nuclear vacuolation, nuclear fragmentation and nuclear disintegration. A remarkable modification of red blood cell surface morphology was observed in the result of RBC assay. The treated RBCs show membrane blebbing and shrinkage, features typical for apoptosis in nucleated cells. Significant induction of cell death was observed in treated Allium root tip cells after Evans blue staining, disclosing the membrane damage potential of the plant extract. TTC assay results in reduced mitochondrial/metabolic activity in Allium root tip cells after treatment, designating the adverse effect of plant extract on mitochondrial respiratory chain. These results confirm the apoptosis inducing potential of A. spinosus extract. Confirming the present results by further in vitro studies, it can be effectively targeted against cell proliferation during cancer treatment by inducing apoptosis. Thus from the present investigation it can be concluded that the aqueous extract of A. spinosus exhibited apoptosis induction and cytotoxic activities.
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