Evidence map›Paper›PMID 27896427›Full record

ArticleEuropean journal of pediatrics2017

Predictors of motor developmental milestones during the first year of life.

Trine Flensborg-Madsen, Erik Lykke Mortensen

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Article in European journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Trine Flensborg-MadsenUnit of Medical Psychology, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5A, 1353, Copenhagen K, Denmark. tfma@sund.ku.dk.ORCID http://orcid.org/0000-0002-6753-335X
Erik Lykke MortensenUnit of Medical Psychology, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5A, 1353, Copenhagen K, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies suggest that both pre- and postnatal factors are predictors of age of attaining milestones in infancy. However, no studies evaluate the comparative strength of these predictors and the amount of the variance in development they explain. This study aimed to conduct a systematic evaluation of a broad selection of possible predictors of age at milestone attainment and to identify factors that explain significant inter-individual variance. Mothers of 5765 children of the Copenhagen Perinatal Cohort (1959-61) recorded 12 developmental milestones prospectively during the child's first year of life. Information on possible predictors was collected during pregnancy and at follow-up and was categorized into the domains: Family background, Pregnancy and delivery, Postnatal influences, and Postnatal growth. The domain Pregnancy and delivery contributed most of the explained variance in Overall mean of milestones (14.4%), with especially gestational age (β = -0.15; p ≤ 0.001) and birth weight (β = -0.16; p ≤ 0.001) being important predictors.

conclusionSeveral individual factors, especially gestational age, birth weight, breastfeeding, having lived in a full-time institution, and weight and head increase in the first year, were significantly associated with milestone attainment in the first year of life. Variables within the domain of Pregnancy and delivery explained the largest proportion of variance in milestone attainment compared to the other domains. What is known: • Younger age at attainment of motor developmental milestones positively predicts cognitive outcomes in adulthood. • Both pre- and postnatal factors have been associated with age of attaining milestones in infancy. What is new: • First study to provide a systematic evaluation of a broad selection of predictors of infant milestone attainment. • Variables within the domain of Pregnancy and delivery, especially gestational age and birth weight, explained the largest proportion of variance in milestone attainment. • The variance explained by the predictors decreased time-dependently with later milestones.

Indexed as

AdultBirth WeightBreast FeedingChild DevelopmentFemaleFollow-Up StudiesGestational AgeHumansInfantInfant, NewbornLinear ModelsMaleMothersPregnancyRetrospective StudiesSocioeconomic FactorsBirth cohortInfant developmentLongitudinal studyMotor developmental milestonesPostnatal factorsPregnancy

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.