ArticleeNeuro
Graph Theoretic and Motif Analyses of the Hippocampal Neuron Type Potential Connectome.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Hippocampome.org, a resource for subicular neuron types and beyond.bioRxiv : the preprint server for biology · 2025Article
- Organization and Community Usage of a Neuron Type Circuitry Knowledge Base of the Hippocampal Formation.Biomedicines · 2025Article
- A Continuous Attractor Model with Realistic Neural and Synaptic Properties Quantitatively Reproduces Grid Cell Physiology.International journal of molecular sciences · 2024Article
- A Continuous Attractor Model with Realistic Neural and Synaptic Properties Quantitatively Reproduces Grid Cell Physiology.bioRxiv : the preprint server for biology · 2024Article
- Article
- Hippocampome.org v2.0: a knowledge base enabling data-driven spiking neural network simulations of rodent hippocampal circuits.bioRxiv : the preprint server for biology · 2024Article
- Neurodynamical Computing at the Information Boundaries of Intelligent Systems.Cognitive computation · 2024Article
- Robust Resting-State Dynamics in a Large-Scale Spiking Neural Network Model of Area CA3 in the Mouse Hippocampus.Cognitive computation · 2023Article
- Hippocampal non-theta state: The "Janus face" of information processing.Frontiers in neural circuits · 2023Review
- Quantification of neuron types in the rodent hippocampal formation by data mining and numerical optimization.The European journal of neuroscience · 2022Article
- Spiking Neural Networks and Hippocampal Function: A Web-Accessible Survey of Simulations, Modeling Methods, and Underlying Theories.Cognitive systems research · 2021Article
- An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo.PLoS biology · 2021Article
- Use of random matrix theory in the discovery of resting state brain networks.Magnetic resonance imaging · 2021Article
- Comprehensive Estimates of Potential Synaptic Connections in Local Circuits of the Rodent Hippocampal Formation by Axonal-Dendritic Overlap.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Integrative Models of Brain Structure and Dynamics: Concepts, Challenges, and Methods.Frontiers in neuroscience · 2021Review
- The human olfactory system in two proteinopathies: Alzheimer's and Parkinson's diseases.Translational neurodegeneration · 2020Review
- A comprehensive knowledge base of synaptic electrophysiology in the rodent hippocampal formation.Hippocampus · 2020Article
- Rich-club in the brain's macrostructure: Insights from graph theoretical analysis.Computational and structural biotechnology journal · 2020Review
- Quantitative firing pattern phenotyping of hippocampal neuron types.Scientific reports · 2019Article
- Simple models of quantitative firing phenotypes in hippocampal neurons: Comprehensive coverage of intrinsic diversity.PLoS computational biology · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We computed the potential connectivity map of all known neuron types in the rodent hippocampal formation by supplementing scantly available synaptic data with spatial distributions of axons and dendrites from the open-access knowledge base Hippocampome.org. The network that results from this endeavor, the broadest and most complete for a mammalian cortical region at the neuron-type level to date, contains more than 3200 connections among 122 neuron types across six subregions. Analyses of these data using graph theory metrics unveil the fundamental architectural principles of the hippocampal circuit. Globally, we identify a highly specialized topology minimizing communication cost; a modular structure underscoring the prominence of the trisynaptic loop; a core set of neuron types serving as information-processing hubs as well as a distinct group of particular antihub neurons; a nested, two-tier rich club managing much of the network traffic; and an innate resilience to random perturbations. At the local level, we uncover the basic building blocks, or connectivity patterns, that combine to produce complex global functionality, and we benchmark their utilization in the circuit relative to random networks. Taken together, these results provide a comprehensive connectivity profile of the hippocampus, yielding novel insights on its functional operations at the computationally crucial level of neuron types.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.