Evidence map›Paper›PMID 27896310›Full record

ArticleeNeuro

Preservation of Essential Odor-Guided Behaviors and Odor-Based Reversal Learning after Targeting Adult Brain Serotonin Synthesis.

Kaitlin S Carlson, Meredith S Whitney, Marie A Gadziola, Evan S Deneris, Daniel W Wesson

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Acute psilocybin enhances cognitive flexibility in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  5. Article
  6. Acute psilocybin enhances cognitive flexibility in rats.bioRxiv : the preprint server for biology · 2023
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Serotonergic afferents from the dorsal raphe decrease the excitability of pyramidal neurons in the anterior piriform cortex.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  13. Review
  14. Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kaitlin S CarlsonDepartment of Neurosciences, Case Western Reserve University , Cleveland, OH, 44106.
Meredith S WhitneyDepartment of Neurosciences, Case Western Reserve University , Cleveland, OH, 44106.ORCID 0000-0002-1013-6599
Marie A GadziolaDepartment of Neurosciences, Case Western Reserve University , Cleveland, OH, 44106.ORCID 0000-0003-2435-8157
Evan S DenerisDepartment of Neurosciences, Case Western Reserve University , Cleveland, OH, 44106.ORCID 0000-0003-4211-9934
Daniel W WessonDepartment of Neurosciences, Case Western Reserve University , Cleveland, OH, 44106.ORCID 0000-0002-3192-3866
Case Western Reserve University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
Stress-Mediated Alterations in Serotonin 2C Receptor Editing and FunctionP50MH096972 · NIMH · VANDERBILT UNIVERSITY · PI EMESON, RONALD B. · 2012 to 2016
$10.5M
PET 1 ETS FACTOR IN THE MAMMALIAN 5 HT SYSTEMR01MH062723 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI DENERIS, EVAN S · 2001 to 2021
$8.3M
INTER-REGIONAL CODING OF ODOR VALENCE BY NEURAL ENSEMBLESR01DC014443 · NIDCD · UNIVERSITY OF FLORIDA · PI WESSON, DANIEL W · 2015 to 2019
$2.3M
Postnatal Serotonin Deficits in Behavioral Pathogenesis: A Novel Genetic ApproachF30MH099704 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI WHITNEY, MEREDITH SORENSON · 2013 to 2015
$128k
Attentional modulation of olfaction in miceF31DC014615 · NIDCD · CASE WESTERN RESERVE UNIVERSITY · PI ZALCIKOVA, KAITLIN · 2015 to 2017
$101k
NIDCD NIH HHS F31 DC014615NIDCD NIH HHS R01 DC014443NIGMS NIH HHS T32 GM007250NIMH NIH HHS F30 MH099704NIMH NIH HHS P50 MH096972NIMH NIH HHS R01 MH062723
6 · The paper itself

Abstract

The neurotransmitter serotonin (5-HT) is considered a powerful modulator of sensory system organization and function in a wide range of animals. The olfactory system is innervated by midbrain 5-HT neurons into both its primary and secondary odor-processing stages. Facilitated by this circuitry, 5-HT and its receptors modulate olfactory system function, including odor information input to the olfactory bulb. It is unknown, however, whether the olfactory system requires 5-HT for even its most basic behavioral functions. To address this question, we established a conditional genetic approach to specifically target adult brain

Indexed as

AnimalsBody WeightDiscrimination LearningDiscrimination, PsychologicalDrinkingDrinking WaterExecutive FunctionInhibition, PsychologicalMaleMice, TransgenicMotor ActivityOlfactory PerceptionProsencephalonReversal LearningSerotoninSynaptic TransmissionDrinking WaterSerotoninTph2 protein, mouseTryptophan Hydroxylase5-HTodor discriminationodor learningoperant behaviorpsychophysicsreversal learning

Identifiers

PMID27896310
PMCPMC5112565
OpenAlexW2539556954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.