Evidence map›Paper›PMID 27896287›Full record

ArticleMolecular genetics & genomic medicine2016

Enamel ribbons, surface nodules, and octacalcium phosphate in C57BL/6

Yuanyuan Hu, Charles E Smith, Zhonghou Cai, Lorenza A-J Donnelly, Jie Yang, Jan C-C Hu, James P Simmer

Open access · goldAbstract read
In one paragraph

Article in Molecular genetics & genomic medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  3. Amelogenin Null Mice Develop Osteoarthritis, While Its Application Mitigates Disease Phenotypes in a Rat Model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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  4. Functions of secretory calcium-binding phosphoproteins in dental mineralization.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Role of amelogenin phosphorylation in regulating dental enamel formation.Matrix biology : journal of the International Society for Matrix Biology · 2024
    Article
  9. International journal of molecular sciences · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. High-yield recombinant bacterial expression ofProtein science : a publication of the Protein Society · 2023
    Article
  14. Article
  15. Enamel defects in Acp4Scientific reports · 2022
    Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Yuanyuan HuDepartment of Biologic and Materials Sciences University of Michigan School of Dentistry 1210 Eisenhower Place Ann Arbor Michigan 48108.
Charles E SmithDepartment of Biologic and Materials SciencesUniversity of Michigan School of Dentistry1210Eisenhower PlaceAnn ArborMichigan48108; Facility for Electron Microscopy ResearchDepartment of Anatomy and Cell BiologyFaculty of DentistryMcGill UniversityMontrealQuebecH3A 2B2Canada.
Zhonghou CaiAdvanced Photon Source Argonne National Laboratory 9700 S. Cass Ave Building 431-B005 Argonne Illinois 60439.
Lorenza A-J DonnellyDepartment of Biologic and Materials Sciences University of Michigan School of Dentistry 1210 Eisenhower Place Ann Arbor Michigan 48108.
Jie YangDepartment of Biologic and Materials SciencesUniversity of Michigan School of Dentistry1210Eisenhower PlaceAnn ArborMichigan48108; Department of Pediatric DentistrySchool and Hospital of StomatologyPeking University22 South AvenueZhongguancun Haidian DistrictBeijing100081China.
Jan C-C HuDepartment of Biologic and Materials Sciences University of Michigan School of Dentistry 1210 Eisenhower Place Ann Arbor Michigan 48108.
James P SimmerDepartment of Biologic and Materials Sciences University of Michigan School of Dentistry 1210 Eisenhower Place Ann Arbor Michigan 48108.
University of Michigan–Ann Arbor · USArgonne National Laboratory · USPeking University · CN

Funding

Proteomics and Genetics of Enamel and DentinR01DE015846 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HU, JAN CHING CHUN · 2004 to 2019
$5.7M
NIDCR NIH HHS R01 DE015846
6 · The paper itself

Abstract

backgroundAmelogenin is required for normal enamel formation and is the most abundant protein in developing enamel.

methods

resultsNo amelogenin protein was detected by Western blot analyses of enamel extracts from

conclusionAmelogenin forms a resorbable matrix that separates and supports, but does not shape early secretory-stage enamel ribbons. Amelogenin may facilitate the conversion of enamel ribbons into hydroxyapatite by inhibiting the formation of octacalcium phosphate. Amelogenin is necessary for thickening the enamel layer, which helps maintain ribbon organization and development and maintenance of the Tomes' process.

Indexed as

Ameloblastamelogenesis imperfectaamelogeninamorphous calcium phosphateenamelincisormolaroctacalcium phosphate

Identifiers

PMID27896287
PMCPMC5118209
OpenAlexW2527885332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.