ArticleWorld journal of critical care medicine2016
Plasma-Lyte 148: A clinical review.
Article in World journal of critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Plasma-lyte solution versus saline in kidney transplantation: A systematic review and meta-analysis of randomized controlled trials.PloS one · 2025Pooled it
- PlasmaLyte, Lactated Ringer's, or Normal Saline resuscitation in acute pancreatitis: a single-center, pragmatic, cluster-randomized trial.BMC gastroenterology · 2026Trial
- Evaluation of the effects of Plasma-Lyte 148 or 0.9% saline on acid-base balance in patients undergoing neurosurgery: a randomized clinical trial.Einstein (Sao Paulo, Brazil) · 2026Trial
- Trial
- Sodium chloride or Plasmalyte-148 evaluation in severe diabetic ketoacidosis (SCOPE-DKA): a cluster, crossover, randomized, controlled trial.Intensive care medicine · 2021Trial
- Trial
- Trial
- Clinical Effects of Balanced Crystalloids vs Saline in Adults With Diabetic Ketoacidosis: A Subgroup Analysis of Cluster Randomized Clinical Trials.JAMA network open · 2020Trial
- Effects of balanced solution on short-term outcomes in traumatic brain injury patients: a secondary analysis of the BaSICS randomized trial.Revista Brasileira de terapia intensivaTrial
- Comparison of ringer's lactate and plasmalyt-a as cardiopulmonary bypass prime for bypass associated acidosis in valve replacement surgeries.Annals of cardiac anaesthesiaTrial
- Successful treatment of severe iatrogenic hypercalcemia and acute kidney injury with hemodialysis in a cat.Journal of veterinary internal medicine · 2026Article
- Maintenance and resuscitation fluids for brain injury: keep them salty and not too sweet but mind the kidney.Intensive care medicine · 2025Article
- CARI Guideline: Evidence-Based Recommendations for Balanced Electrolyte Solutions to Improve Kidney Transplant Outcomes.Kidney international reports · 2025Article
- Is Plasmalyte beneficial in the resuscitation of diabetic ketoacidosis patients? A narrative review.Clinical and experimental emergency medicine · 2025Article
- Buffered salt solution versus 0.9% sodium chloride as fluid therapy for patients presenting with moderate to severe diabetic ketoacidosis: Study protocol for a Phase-3 cluster-crossover, blinded, randomised, controlled trial.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Article
- Perioperative fluid therapy in adults and children: a narrative review.Frontiers in medicine · 2025Review
- Effect of Fluid Therapy on Acid-Base Balance in Patients Undergoing Clipping for Ruptured Intracranial Aneurysm: A Prospective Randomized Controlled Trial.Asian journal of neurosurgery · 2024Article
- Potassium level changes in chronic kidney disease patients following balanced crystalloid administration in the emergency department.Medicine · 2023Article
- Role of Crystalloids in the Perioperative Setting: From Basics to Clinical Applications and Enhanced Recovery Protocols.Journal of clinical medicine · 2023Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo outline the physiochemical properties and specific clinical uses of Plasma-Lyte 148 as choice of solution for fluid intervention in critical illness, surgery and perioperative medicine.
methodsWe performed an electronic literature search from Medline and PubMed (
resultsWe retrieved 104 articles relevant to the choice of Plasma-Lyte 148 for fluid intervention in critical illness, surgery and perioperative medicine. We analyzed the data and reported the results in tables and text.
conclusionPlasma-Lyte 148 is an isotonic, buffered intravenous crystalloid solution with a physiochemical composition that closely reflects human plasma. Emerging data supports the use of buffered crystalloid solutions in preference to saline in improving physicochemical outcomes. Further large randomized controlled trials assessing the comparative effectiveness of Plasma-Lyte 148 and other crystalloid solutions in measuring clinically important outcomes such as morbidity and mortality are needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.