ReviewBiomolecular detection and quantification2014
The reproducibility of biomedical research: Sleepers awake!
Review in Biomolecular detection and quantification, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A resting state fMRI analysis pipeline for pooling inference across diverse cohorts: an ENIGMA rs-fMRI protocol.Brain imaging and behavior · 2019Pooled it
- Interpretations of reproducibility crisis in medical education research: a qualitative study.Scientific reports · 2026Article
- Experimental reporting of fish transcriptomic responses in environmental toxicology and ecotoxicology.Environmental toxicology and chemistry · 2025Review
- Optimized bacterial absolute quantification method by qPCR using an exogenous bacterial culture as a normalization strategy in triple-species BV-like biofilms.Journal of microbiological methods · 2024Article
- Article
- A Strategy for the Selection of RT-qPCR Reference Genes Based on Publicly Available Transcriptomic Datasets.Biomedicines · 2023Article
- Rigor, Reproducibility, and Transparency in Shared Research Resources: Follow-Up Survey and Recommendations for Improvements.Journal of biomolecular techniques : JBT · 2022Article
- CRISPR-Cas, Argonaute proteins and the emerging landscape of amplification-free diagnostics.Methods (San Diego, Calif.) · 2022Article
- Application of a High-Throughput Targeted Sequence AmpliSeq Procedure to Assess the Presence and Variants of Virulence Genes inMicroorganisms · 2022Article
- Upregulation of circular and linear METTL3 and USP3 in colorectal cancer.Oncology letters · 2021Article
- COVID-19 and Diagnostic Testing for SARS-CoV-2 by RT-qPCR-Facts and Fallacies.International journal of molecular sciences · 2021Article
- Prospects and challenges of multi-omics data integration in toxicology.Archives of toxicology · 2020Review
- The Impact of Acute Loud Noise on the Behavior of Laboratory Birds.Frontiers in veterinary science · 2020Article
- uap: reproducible and robust HTS data analysis.BMC bioinformatics · 2019Article
- Survey on Scientific Shared Resource Rigor and Reproducibility.Journal of biomolecular techniques : JBT · 2019Article
- On resolving ambiguities in microbial community analysis of partial nitritation anammox reactors.Scientific reports · 2019Article
- Algorithms for automated detection of hook effect-bearing amplification curves.Biomolecular detection and quantification · 2018Article
- The neuronal migration hypothesis of dyslexia: A critical evaluation 30 years on.The European journal of neuroscience · 2018Review
- Improving the standardization of mRNA measurement by RT-qPCR.Biomolecular detection and quantification · 2018Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is increasing concern about the reliability of biomedical research, with recent articles suggesting that up to 85% of research funding is wasted. This article argues that an important reason for this is the inappropriate use of molecular techniques, particularly in the field of RNA biomarkers, coupled with a tendency to exaggerate the importance of research findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.