Evidence map›Paper›PMID 27896108›Full record

ArticleMolecular genetics and metabolism reports2014

Association of genetic variants of the incretin-related genes with quantitative traits and occurrence of type 2 diabetes in Japanese.

Mayumi Enya, Yukio Horikawa, Katsumi Iizuka, Jun Takeda

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics and metabolism reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mayumi EnyaDepartment of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan.
Yukio HorikawaDepartment of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan.
Katsumi IizukaDepartment of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan.
Jun TakedaDepartment of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan.
Gifu University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNone of the high frequency variants of the incretin-related genes has been found by genome-wide association study (GWAS) for association with occurrence of type 2 diabetes in Japanese. However, low frequency and rare and/or high frequency variants affecting glucose metabolic traits remain to be investigated.

methodWe screened all exons of the incretin-related genes (

resultTwo mutations of

conclusionRare variants of

Indexed as

BMI, body mass indexCPR, c-peptide immunoreactivityDPP4, dipeptidyl peptidase 4GCG, proglucagon geneGIP, glucose-dependent insulinotropic peptideGIPR, GIP receptorGLP-1, glucagon-like peptide 1GLP1R, GLP-1 receptorGWAS, genome-wide association studyHbA1c, hemoglobin A1cHOMA-B, homeostasis model assessment as an index of insulin secretionHOMA-R, homeostasis model assessment as an index of insulin resistanceIncretinIRI, immunoreactive insulinLD, linkage disequilibriumObesityOR, odds ratioPCR, polymerase chain reactionPCSK1PCSK1, prohormone convertase (PC) enzymes. PC1/3PolymorphismSNP, single nucleotide polymorphismType 2 diabetes

Identifiers

PMID27896108
PMCPMC5121356
OpenAlexW2082607501

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.