Evidence map›Paper›PMID 27896096›Full record

ArticleMolecular genetics and metabolism reports2014

Peripheral leukocyte anomaly detected with routine automated hematology analyzer sensitive to adipose triglyceride lipase deficiency manifesting neutral lipid storage disease with myopathy/triglyceride deposit cardiomyovasculopathy.

Akira Suzuki, Hironori Nagasaka, Yasuhiro Ochi, Kazuhiro Kobayashi, Hiroshi Nakamura, Daisaku Nakatani, Satoshi Yamaguchi, Shinobu Yamaki, Atsushi Wada, Yoshihisa Shirata and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics and metabolism reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Akira SuzukiLaboratory of Cardiovascular Disease, Novel, Non-invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University, Suita, Osaka 565-0874, Japan.
Hironori NagasakaDepartment of Pediatrics, Takarazuka City Hospital, Takarazuka 665-0827, Japan.
Yasuhiro OchiScientific Affairs, Sysmex Corporation, Kobe 651-2241, Japan.
Kazuhiro KobayashiDivision of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Hiroshi NakamuraDepartment of Community Health and Medicine, Yamaguchi University, School of Medicine, Ube 755-8505, Japan.
Daisaku NakataniLaboratory of Cardiovascular Disease, Novel, Non-invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University, Suita, Osaka 565-0874, Japan.
Satoshi YamaguchiLaboratory of Cardiovascular Disease, Novel, Non-invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University, Suita, Osaka 565-0874, Japan.
Shinobu YamakiFaculty of Health Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Atsushi WadaScientific Affairs, Sysmex Corporation, Kobe 651-2241, Japan.
Yoshihisa ShirataSapporo Branch, Sysmex Corporation, Sapporo 060-0002, Japan.
Shu-Ping HuiFaculty of Health Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Tatsushi TodaDivision of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Hiroshi KurodaDepartment of Neurology, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Hitoshi ChibaFaculty of Health Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Ken-Ichi HiranoLaboratory of Cardiovascular Disease, Novel, Non-invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University, Suita, Osaka 565-0874, Japan.
The University of Osaka · JPHealth Sciences University of Hokkaido · JPSysmex (Japan) · JPKobe University · JPTakarazuka City Hospital · JPTohoku University · JPYamaguchi University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipose triglyceride lipase (ATGL) deficiency manifesting neutral lipid storage disease with myopathy/triglyceride deposit cardiomyovasculopathy presents distinct fat-containing vacuoles known as Jordans' anomaly in peripheral leucocytes. To develop an automatic notification system for Jordans' anomaly in ATGL-deficient patients, we analyzed circulatory leukocyte scattergrams on automated hematology analyzer XE-5000. The BASO-WX and BASO-WY values were found to be significantly higher in patients than those in non-affected subjects. The two parameters measured by automated hematology analyzer may be expected to provide an important diagnostic clue for homozygous ATGL deficiency.

Indexed as

Adipose triglyceride lipase deficiencyATGL, adipose triglyceride lipaseAutomated hematology analyzerBASO-WX and BASO-WYCirculatory neutrophilsJordans' anomalyNLSD-M, Neutral lipid storage disease with myopathy (NLSD-M)TGCV, triglyceride deposit cardiomyovasculopathyTriglyceride deposit cardiomyovasculopathy

Identifiers

PMID27896096
PMCPMC5121313
OpenAlexW1994336456

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.