Evidence map›Paper›PMID 27896059›Full record

ArticleApplied & translational genomics2013

Signatures of natural selection on genetic variants affecting complex human traits.

Ge Zhang, Louis J Muglia, Ranajit Chakraborty, Joshua M Akey, Scott M Williams

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied & translational genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Population genetic variation ofJournal of genetics · 2021
    Article
  3. Article
  4. Article
  5. Article
  6. Human Genetic Adaptation to High Altitudes: Current Status and Future Prospects.Quaternary international : the journal of the International Union for Quaternary Research · 2017
    Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ge ZhangHuman Genetics Division, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Louis J MugliaCenter for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center and March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, OH, USA.
Ranajit ChakrabortyCenter for Computational Genomics, Institute of Applied Genetics, University of North Texas Health Science Center, Fort Worth, TX, USA.
Joshua M AkeyDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Scott M WilliamsDepartment of Genetics and Institute for Quantitative Biomedical Sciences, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has recently been hypothesized that polygenic adaptation, resulting in modest allele frequency changes at many loci, could be a major mechanism behind the adaptation of complex phenotypes in human populations. Here we leverage the large number of variants that have been identified through genome-wide association (GWA) studies to comprehensively study signatures of natural selection on genetic variants associated with complex traits. Using population differentiation based methods, such as

Indexed as

Complex traitsGenome-wide associationNatural selectionPolygenic adaptation

Identifiers

PMID27896059
PMCPMC5121263

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.