ReviewApplied & translational genomics2013
Maternal regulation of offspring development in mammals is an ancient adaptation tied to lactation.
Review in Applied & translational genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Non-Coding RNAs in Human Breast Milk: A Systematic Review.Frontiers in immunology · 2021Pooled it
- Impact of prenatal stress on offspring glucocorticoid levels: A phylogenetic meta-analysis across 14 vertebrate species.Scientific reports · 2018Pooled it
- Human Breast Milk miRNA, Maternal Probiotic Supplementation and Atopic Dermatitis in Offspring.PloS one · 2015Trial
- Transitional feeding in developing pigs: Effects of food texture modification on liquid swallowing behavior and epiglottic movements.Physiological reports · 2026Article
- Human milk-derived extracellular vesicles promote the heat shock response in polarized microglia.Cell stress & chaperones · 2025Article
- Connecting microbial ecology to human fertility and reproduction: perspectives from the reproductive microbiomes of animals.F&S reports · 2025Article
- Autotaxin Expression in the Uterus of Cycling Rats.Development & reproduction · 2024Article
- Microbiome: Mammalian milk microbiomes: sources of diversity, potential functions, and future research directions.Reproduction & fertility · 2024Review
- Maternal hsa-miR-423-5p associated with the cognitive development of babies in pregnant women without mental disorders.Frontiers in human neuroscience · 2024Article
- Androgen-mediated maternal effects and trade-offs: postnatal hormone development, growth, and survivorship in wild meerkats.Frontiers in endocrinology · 2024Article
- Ecoevolutionary processes structure milk microbiomes across the mammalian tree of life.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Maternal capital predicts investment in infant growth and development through lactation.Frontiers in nutrition · 2023Article
- Milk microbiomes of three great ape species vary among host species and over time.Scientific reports · 2022Article
- Gestational Exercise Increases Male Offspring's Maximal Workload Capacity Early in Life.International journal of molecular sciences · 2022Article
- Maternal Inactivity Programs Skeletal Muscle Dysfunction in Offspring Mice by Attenuating Apelin Signaling and Mitochondrial Biogenesis.Cell reports · 2020Article
- Maternal exercise attenuates the lower skeletal muscle glucose uptake and insulin secretion caused by paternal obesity in female adult rat offspring.The Journal of physiology · 2020Article
- Increasing serotonin bioavailability alters gene expression in peripheral leukocytes and lymphoid tissues of dairy calves.Scientific reports · 2020Article
- Article
- 'Optimising' breastfeeding: what can we learn from evolutionary, comparative and anthropological aspects of lactation?BMC medicine · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The developmental origins of health and disease (DOHaD) is a paradigm for understanding metabolic diseases of modern humans. Vulnerability to disease is linked to perturbations in development during critical time periods in fetal and neonatal life. These perturbations are caused by environmental signals, often generated or transduced by the mother. The regulation of mammalian development depends to a large extent on maternal biochemical signals to her offspring. We argue that this adaptation is ancient, and originated with the evolution of lactation. Lactation evolved earlier than live birth and before the extensive placental development of modern eutherian mammals. Milk contains a host of signaling molecules including nutrients, immunoglobulins, growth factors and metabolic hormones. As evidenced by marsupials, lactation originally served to supply the biochemical factors for growth and development for what is essentially a fetus to a weanling transitioning to independent existence. In placental mammals maternal signaling in earliest life is accomplished through the maternal-placental-fetal connection, with more of development shifted to
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.