Evidence map›Paper›PMID 27896013›Full record

ArticleBiomedical optics express2016

Using electron microscopy to calculate optical properties of biological samples.

Wenli Wu, Andrew J Radosevich, Adam Eshein, The-Quyen Nguyen, Ji Yi, Lusik Cherkezyan, Hemant K Roy, Igal Szleifer, Vadim Backman

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Wenli WuApplied Physics Program, Northwestern University, Evanston, Illinois 60208, USA.
Andrew J RadosevichDepartment of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA.
Adam EsheinDepartment of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA.
The-Quyen NguyenDepartment of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA.
Ji YiDepartment of Medicine, Boston University, Boston, Massachusetts 02118, USA.
Lusik CherkezyanDepartment of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA.
Hemant K RoySection of Gastroenterology, Boston Medical Center/Boston University School of Medicine, Boston, Massachusetts 02118, USA.
Igal SzleiferDepartment of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA; Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, USA.
Vadim BackmanDepartment of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA; Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, USA.
Northwestern University · USBoston University · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
Spatio-Temporal Organization of Chromatin and Information Transfer in CancerU54CA193419 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BACKMAN, VADIM · 2015 to 2020
$10.4M
Biophotonics to Couple Pancreatic with Upper GI Screening via Ultrathin EndoscopyR01CA183101 · NCI · NORTHWESTERN UNIVERSITY · PI BACKMAN, VADIM, ROGERS, JEREMY D. · 2015 to 2019
$3.2M
In-vivo characterization of pancreatic field carcinogenesis using spatially resolved reflectance measurements via a fiber optic probeF31EB022414 · NIBIB · NORTHWESTERN UNIVERSITY · PI ESHEIN, ADAM · 2016 to 2017
$76k
NCI NIH HHS P30 CA060553NCI NIH HHS R01 CA183101NCI NIH HHS U54 CA193419NIBIB NIH HHS F31 EB022414
6 · The paper itself

Abstract

The microscopic structural origins of optical properties in biological media are still not fully understood. Better understanding these origins can serve to improve the utility of existing techniques and facilitate the discovery of other novel techniques. We propose a novel analysis technique using electron microscopy (EM) to calculate optical properties of specific biological structures. This method is demonstrated with images of human epithelial colon cell nuclei. The spectrum of anisotropy factor g, the phase function and the shape factor D of the nuclei are calculated. The results show strong agreement with an independent study. This method provides a new way to extract the true phase function of biological samples and provides an independent validation for optical property measurement techniques.

Indexed as

(000.1430) Biology and medicine(160.4760) Optical properties(170.3660) Light propagation in tissues(170.4580) Optical diagnostics for medicine

Identifiers

PMID27896013
PMCPMC5119613
OpenAlexW2542385118

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.