ArticleBiomedical optics express2016
Nonlinear characterization of elasticity using quantitative optical coherence elastography.
Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026Review
- Geophysics-Inspired Nonlinear Stress-Strain Law for Biological Tissues and Its Applications in Compression Optical Coherence Elastography.Materials (Basel, Switzerland) · 2024Article
- A novel stress sensor enables accurate estimation of micro-scale tissue mechanics in quantitative micro-elastography.APL bioengineering · 2024Article
- Learning-based distortion correction enables proximal-scanning endoscopic OCT elastography.Biomedical optics express · 2024Article
- Article
- Analysis of friction in quantitative micro-elastography.Biomedical optics express · 2023Article
- Spatio-Temporal Dynamics of Diffusion-Associated Deformations of Biological Tissues and Polyacrylamide Gels Observed with Optical Coherence Elastography.Materials (Basel, Switzerland) · 2023Article
- Intravascular optical coherence elastography.Biomedical optics express · 2022Article
- Nonlinear Elasticity Assessment with Optical Coherence Elastography for High-Selectivity Differentiation of Breast Cancer Tissues.Materials (Basel, Switzerland) · 2022Article
- Compression optical coherence elastography versus strain ultrasound elastography for breast cancer detection and differentiation: pilot study.Biomedical optics express · 2022Article
- Quantitative characterization of human breast tissue based on deep learning segmentation of 3D optical coherence tomography images.Biomedical optics express · 2021Article
- Analysis of sensitivity in quantitative micro-elastography.Biomedical optics express · 2021Article
- Measuring and Modelling Nonlinear Elasticity of Ex Vivo Mouse Muscles.Journal of healthcare engineering · 2021Article
- Clinical Corneal Optical Coherence Elastography Measurement Precision: Effect of Heartbeat and Respiration.Translational vision science & technology · 2020Article
- Laser-induced elastic wave classification: thermoelastic versus ablative regimes for all-optical elastography applications.Journal of biomedical optics · 2020Article
- Spatial coordinate corrected motion tracking for optical coherence elastography.Proceedings of SPIE--the International Society for Optical Engineering · 2020Article
- Three-dimensional imaging of cell and extracellular matrix elasticity using quantitative micro-elastography.Biomedical optics express · 2020Article
- Spatial coordinate corrected motion tracking for optical coherence elastography.Biomedical optics express · 2019Article
- Photoacoustic elastography imaging: a review.Journal of biomedical optics · 2019Review
- Quantitative Optical Coherence Elastography for Robust Stiffness Assessment.Applied sciences (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optical coherence elastography (OCE) has been used to perform mechanical characterization on biological tissue at the microscopic scale. In this work, we used quantitative optical coherence elastography (qOCE), a novel technology we recently developed, to study the nonlinear elastic behavior of biological tissue. The qOCE system had a fiber-optic probe to exert a compressive force to deform tissue under the tip of the probe. Using the space-division multiplexed optical coherence tomography (OCT) signal detected by a spectral domain OCT engine, we were able to simultaneously quantify the probe deformation that was proportional to the force applied, and to quantify the tissue deformation. In other words, our qOCE system allowed us to establish the relationship between mechanical stimulus and tissue response to characterize the stiffness of biological tissue. Most biological tissues have nonlinear elastic behavior, and the apparent stress-strain relationship characterized by our qOCE system was nonlinear an extended range of strain, for a tissue-mimicking phantom as well as biological tissues. Our experimental results suggested that the quantification of force in OCE was critical for accurate characterization of tissue mechanical properties and the qOCE technique was capable of differentiating biological tissues based on the elasticity of tissue that is generally nonlinear.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.