Evidence map›Paper›PMID 27895982›Full record

ArticleBiomedical optics express2016

Extended-focus optical coherence microscopy for high-resolution imaging of the murine brain.

Szymon Tamborski, Hong Chou Lyu, Hubert Dolezyczek, Monika Malinowska, Grzegorz Wilczynski, Daniel Szlag, Theo Lasser, Maciej Wojtkowski, Maciej Szkulmowski

Abstract read
In one paragraph

Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Optical Coherence Microscopy for Oocyte Imaging.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Neurophotonics · 2020
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Szymon TamborskiInstitute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University Grudziadzka 5, 87-100 Torun, Poland.
Hong Chou LyuInstitute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University Grudziadzka 5, 87-100 Torun, Poland.
Hubert DolezyczekNencki Institute of Experimental Biology, 3 Pasteur Street, 02-093 Warsaw, Poland.
Monika MalinowskaNencki Institute of Experimental Biology, 3 Pasteur Street, 02-093 Warsaw, Poland.
Grzegorz WilczynskiNencki Institute of Experimental Biology, 3 Pasteur Street, 02-093 Warsaw, Poland.
Daniel SzlagLaboratoire d'Optique Biomédicale, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
Theo LasserLaboratoire d'Optique Biomédicale, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
Maciej WojtkowskiInstitute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University Grudziadzka 5, 87-100 Torun, Poland.
Maciej SzkulmowskiInstitute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University Grudziadzka 5, 87-100 Torun, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We propose a new method and optical instrumentation for mouse brain imaging based on extended-focus optical coherence microscopy. This in vivo imaging technique allows the evaluation of the cytoarchitecture at cellular level and the circulation system dynamics in three dimensions. This minimally invasive and non-contact approach is performed without the application of contrasting agents. The optical design achieved a resolution of 2.2 μm over a distance of 800 μm, which was sufficient to obtain a detailed three-dimensional image of a wild-type mouse's brain down to the layer III of the cortex. Intrinsically contrasted microvessels and structures similar to the bodies of neurons were distinguishable.

Indexed as

(110.2945) Illumination design(110.3175) Interferometric imaging(110.4500) Optical coherence tomography(170.3880) Medical and biological imaging

Identifiers

PMID27895982
PMCPMC5119582

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.