Evidence map›Paper›PMID 27895937›Full record

ReviewJournal of ophthalmology2016

Medical Management of Glaucoma in the 21st Century from a Canadian Perspective.

Paul Harasymowycz, Catherine Birt, Patrick Gooi, Lisa Heckler, Cindy Hutnik, Delan Jinapriya, Lesya Shuba, David Yan, Radmila Day

2 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Journal of ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 60 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 3 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04609345 unknown statusnot on this mapstarted 2020, after this paper: background citation

Prevalence of Ocular Surface Disease in Malaysian Glaucoma Patients

TypeobservationalSponsorSanten Pharma Malaysia Sdn BhdRan2020 to 2021Enrolled400ConditionsPrimary Open-angle Glaucoma, Primary Angle-Closure Glaucoma, Pseudoexfoliation Glaucoma, Pigment Dispersion Glaucoma
NCT07777861 phase2recruitingnot on this mapstarted 2026, after this paper: background citation

A Randomized, Double-Masked, Placebo-Controlled Phase II Clinical Trial Evaluating the Efficacy and Safety of G01 Eye Drops in the Treatment of Optic Nerve Injury Associated With Open-Angle Glaucoma

TypeinterventionalSponsorQingdao WanMing BioCell Pharmaceutics Co.,Ltd.Ran2026 to 2027Enrolled90ConditionsPrimary Open-Angle Glaucoma, Optic Nerve InjuryArmsG01 Eye Drops 100μg/ml, G01 Eye Drops 200μg/ml, Placebo of G01 Eye Drops
3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 3 syntheses or guidelines pooled it, 135 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Article
  7. Lens extraction combined with circumferential ab interno trabeculotomy to treat pigmentary glaucoma.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Epigenetics in Glaucoma.Medicina (Kaunas, Lithuania) · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Paul HarasymowyczUniversité de Montréal, Montreal, QC, Canada.ORCID 0000-0003-2524-7811
Catherine BirtUniversity of Toronto, Toronto, ON, Canada.
Patrick GooiUniversity of Calgary, Calgary, AB, Canada.
Lisa HecklerUniversité de Montréal, Montreal, QC, Canada.
Cindy HutnikWestern University, London, ON, Canada.
Delan JinapriyaQueen's University, Kingston, ON, Canada.
Lesya ShubaDalhousie University, Halifax, NS, Canada.
David YanUniversity of Toronto, Toronto, ON, Canada.
Radmila DaySNELL Medical Communication Inc., Montreal, QC, Canada.
Université de Montréal · CAUniversity of Toronto · CADalhousie University · CAQueen's University · CAUniversity of Calgary · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glaucoma is a medical term describing a group of progressive optic neuropathies characterized by degeneration of retinal ganglion cells and retinal nerve fibre layer and resulting in changes in the optic nerve head. Glaucoma is a leading cause of irreversible vision loss worldwide. With the aging population it is expected that the prevalence of glaucoma will continue to increase. Despite recent advances in imaging and visual field testing techniques that allow establishment of earlier diagnosis and treatment initiation, significant numbers of glaucoma patients are undiagnosed and present late in the course of their disease. This can lead to irreversible vision loss, reduced quality of life, and a higher socioeconomic burden. Selection of therapeutic approaches for glaucoma should be based on careful ocular examination, patient medical history, presence of comorbidities, and awareness of concomitant systemic therapies. Therapy should also be individualized to patients' needs and preferences. Recent developments in this therapeutic field require revisiting treatment algorithms and integration of traditional and novel approaches in order to ensure optimal visual outcomes. This article provides an overview of recent developments and practice trends in the medical management of glaucoma in Canada. A discussion of the surgical management is beyond the scope of this paper.

Identifiers

PMID27895937
PMCPMC5118538
OpenAlexW2553226765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.