ArticleGastroenterology and hepatology from bed to bench2016
Protein-protein interaction network of celiac disease.
Article in Gastroenterology and hepatology from bed to bench, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 48 citations in OpenAlex.
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- Assessment of Immunological Effects of Low-Level Er: YAG Laser Radiation.Journal of lasers in medical sciences · 2022Article
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- Introducing GATA3 as a prominent player in Crohn's disease.Gastroenterology and hepatology from bed to bench · 2020Article
- Immunological reactions by T cell and regulation of crucial genes in treated celiac disease patients.Gastroenterology and hepatology from bed to bench · 2020Article
- Interaction Network Prediction and Analysis of Anorexia Nervosa.Iranian journal of child neurology · 2019Article
- Highlighted role of VEGFA in follow up of celiac disease.Gastroenterology and hepatology from bed to bench · 2019Article
- The critical role of dysregulation of antioxidant activity and carbohydrate metabolism in celiac disease.Gastroenterology and hepatology from bed to bench · 2019Article
- Comparison of cytokine and gene activities in tissue and blood samples of patients with celiac disease.Gastroenterology and hepatology from bed to bench · 2019Article
- Introducing tumor necrosis factor as a prominent player in celiac disease and type 1 diabetes mellitus.Gastroenterology and hepatology from bed to bench · 2019Article
- The Screening of Critical Related Genes in Celiac Disease Based on Intraepithelial Lymphocytes Investigation: A Bioinformatics Analysis.Galen medical journal · 2019Article
- Network analysis of grade II into grade III transition in rectum cancer patients.Gastroenterology and hepatology from bed to bench · 2018Article
- Barrett's esophagus transits to a cancer condition via potential biomarkers.Gastroenterology and hepatology from bed to bench · 2018Article
- Celiac disease microarray analysis based on System Biology Approach.Gastroenterology and hepatology from bed to bench · 2018Article
- Protein-Protein Interaction Network Analysis Revealed a New Prospective of Posttraumatic Stress Disorder.Galen medical journal · 2018Article
- Insulin dysregulation plays a critical role in colon inflammation: a bioinformatics approach.Gastroenterology and hepatology from bed to bench · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe aim of this study is to investigate the Protein-Protein Interaction Network of Celiac Disease.
backgroundCeliac disease (CD) is an autoimmune disease with susceptibility of individuals to gluten of wheat, rye and barley MATERIAL AND
methodsIn the present study, we collected the articles that focused on the proteomic data in celiac disease. According to the gene expression investigations of these articles, 31 candidate proteins were selected for this study. The networks of related differentially expressed protein were explored using Cytoscape 3.3 and the PPI analysis methods such as MCODE and ClueGO.
resultsAccording to the network analysis Ubiquitin C, Heat shock protein 90kDa alpha (cytosolic and Grp94); class A, B and 1 member, Heat shock 70kDa protein, and protein 5 (glucose-regulated protein, 78kDa), T-complex, Chaperon in containing TCP1; subunit 7 (beta) and subunit 4 (delta) and subunit 2 (beta), have been introduced as hub-bottlnecks proteins. HSP90AA1, MKKS, EZR, HSPA14, APOB and CAD have been determined as seed proteins.
conclusionChaperons have a bold presentation in curtail area in network therefore these key proteins beside the other hub-bottlneck proteins may be a suitable candidates biomarker panel for diagnosis, prognosis and treatment processes in celiac disease.
Indexed as
Identifiers
27895852PMC5118851W2556849380What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.