ArticleGastroenterology and hepatology from bed to bench2016
Evaluation of hepatitis C virus intrafamilial transmission among families with one index case, a pilot study from Fars province, Iran.
Article in Gastroenterology and hepatology from bed to bench, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Hepatitis C Virus Infection in the PERSIAN Guilan Cohort Study Population: Intrafamilial Transmission Incidence and Response to SOVODAK-Based Therapy.Health science reports · 2026Article
- Prevalence of HBV, HCV, and HIV Infections among Patients Undergoing Hemodialysis in Fasa, Iran: A Six-Year Follow-up Study.Middle East journal of digestive diseases · 2022Article
- Epidemiologic profile of viral hepatitis B and C in North of Iran: results from PERSIAN Guilan Cohort Study (PGCS).BMC research notes · 2021Article
- Hepatitis C virus infection and its associated factors among prisoners in a Nigerian prison.BMC gastroenterology · 2020Article
- Clustering of hepatitis C virus antibody positivity within households and communities in Punjab, India.Epidemiology and infection · 2019Article
- Risk factors for viral hepatitis C infection in Rwanda: results from a nationwide screening program.BMC infectious diseases · 2019Article
- Risk factors for familial clustering of hepatitis C virus infection in a Chinese Han population: a cross-sectional study.BMC public health · 2018Observational
- Role of intrafamilial transmission in high prevalence of hepatitis C virus in Egypt.Hepatic medicine : evidence and research · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimOur aim was to survey the rate and risk factors for Hepatitis C virus interfamilial transmission among families with one index case.
backgroundThe role of intrafamilial transmission in Hepatitis C virus epidemiology is still debated. PATIENTS AND
methodsA cross-sectional study was conducted on 34 families (236 members) of HCV infected patients from Fars province, spring to summer 2013. All subjects were first evaluated for the risk factors of exposure and then their serum was checked for the presence of HCV antibody and the genome, using ELISA and PCR. The genotype of all PCR positive cases was also determined by a commercial assay. Two independent sample t test and Chi-Square test were used to compare groups together.
resultsIn 18 out of 34 families, HCV antibody was detected (52.9%) in new members. Among them, HCV transmission in 11 families (32%) was also confirmed by PCR. Having a history of intravenous drug abuse (P=0.006) and incarceration (P=0.01) showed to be important risk factors for interfamilial transmission. Hence, blade/needle sharing (P=0.016) just following molecular assay and sex (P=036) only in the serologic analysis were also determined as significant risk factors. Furthermore, based on serologic results, medium socioeconomic state was further associated with this manner of transmission (P=0.019 and P=0.328). Interestingly, among relatives, 13 cases were brothers while just 5 cases were couples. The genotypes 3a and 1a were more prevalent among the population.
conclusionIn conclusion, our finding highlighted a noticeable role of interfamilial transmission for HCV spread and supports the significant role of close relatives, especially brother relationship in this spread. Hence, the socioeconomic state was associated with the transmission rate of virus in the family.
Indexed as
Identifiers
27895850PMC5118849W2531065330What OpenQuestion holds
Registered trials
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