Evidence map›Paper›PMID 27895791›Full record

ArticleOncology letters2016

Nedaplatin enhanced apoptotic effects of ABT-737 in human cancer cells via Mcl-1 inhibition.

Chong Zhang, Yang-Ling Li, Xu Weng, Li-Yan Li, Ming-Xian Zhou, Da-Yong Zhang, Neng-Ming Lin

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. BH3-mimetics: recent developments in cancer therapy.Journal of experimental & clinical cancer research : CR · 2021
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Chong ZhangSchool of Medicine, Zhejiang University City College, Hangzhou, Zhejiang 310015, P.R. China.
Yang-Ling LiDepartment of Clinical Pharmacy, Hangzhou First People's Hospital, Hangzhou, Zhejiang 310006, P.R. China; Hangzhou Translational Medicine Research Center, Hangzhou First People's Hospital, Hangzhou, Zhejiang 310006, P.R. China.
Xu WengThe First Affiliated Hangzhou Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China.
Li-Yan LiThe First Affiliated Hangzhou Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China; Department of Pharmacy, Yongkang Hospital of Traditional Chinese Medicine, Yongkang, Zhejiang 321300, P.R. China.
Ming-Xian ZhouSchool of Medicine, Zhejiang University City College, Hangzhou, Zhejiang 310015, P.R. China.
Da-Yong ZhangSchool of Medicine, Zhejiang University City College, Hangzhou, Zhejiang 310015, P.R. China.
Neng-Ming LinDepartment of Clinical Pharmacology, Affiliated Hangzhou Hospital, Nanjing Medical University, Hangzhou, Zhejiang 310006, P.R. China; The First Affiliated Hangzhou Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China; Laboratory of Clinical Pharmacy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China.
Zhejiang University · CNZhejiang Chinese Medical University · CNHangzhou First People's Hospital · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Platinum compounds, such as cisplatin, carboplatin, oxaliplatin and nedaplatin, are widely used to treat a number of solid malignancies. Nedaplatin is a second-generation platinum complex, based on its pronounced anti-cancer activities against several solid tumors being equivalent to that of cisplatin, but with lower nephrotoxicity. In this context, the present study aimed to investigate the potential anti-cancer effect by combining nedaplatin with ABT-737. It was found that nedaplatin greatly increased ABT-737-mediated apoptosis in A549 and 95-D cells, accompanied by enhanced cleavage of poly(ADP-ribose) polymerase and caspase-3. In addition, this enhancement was also paralleled by cytochrome

Indexed as

ABT-737cancercombinationMcl-1nedaplatin

Identifiers

PMID27895791
PMCPMC5104256
OpenAlexW2523340797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.