ReviewBiotechnology for biofuels2016
The dilemma for lipid productivity in green microalgae: importance of substrate provision in improving oil yield without sacrificing growth.
Review in Biotechnology for biofuels, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 160 citations in OpenAlex.
- Concentration-Dependent Effects of Salicylic Acid and Methyl Salicylate on Chlorophylls, Carotenoids, Fatty Acids, and Phenolic Compounds in the Green MicroalgaMarine drugs · 2026Article
- Integrated Production of Microalgal Oil fromFoods (Basel, Switzerland) · 2026Article
- Harnessing microalgae for bioproducts: innovations in synthetic biology.World journal of microbiology & biotechnology · 2025Review
- NanoencapsulatedMolecules (Basel, Switzerland) · 2025Article
- Insect Lipids as Novel Source for Future Applications: Chemical Composition and Industry Applications-A Comprehensive Review.Food science & nutrition · 2025Review
- Kinetic parameters ofPeerJ · 2025Article
- Metabolic response to a heterologous poly-3-hydroxybutyrate (PHB) pathway in Phaeodactylum tricornutum.Applied microbiology and biotechnology · 2024Article
- Nutritional Quality of Basal Resource in Stream Food Webs Increased with Light Reduction-Implications for Riparian Revegetation.Microbial ecology · 2024Article
- Low-dose ionizing radiation generates a hormetic response to modify lipid metabolism in Chlorella sorokiniana.Communications biology · 2024Article
- Assessment of heavy metals and environmental stress conditions on the production potential of polyunsaturated fatty acids (PUFAs) in indigenous microalgae isolated from the Gulf of Mannar coastal waters.Environmental monitoring and assessment · 2024Article
- Article
- Sustainable production of biofuels from the algae-derived biomass.Bioprocess and biosystems engineering · 2023Article
- New insights into raceway cultivation of Euglena gracilis under long-term semi-continuous nitrogen starvation.Scientific reports · 2023Article
- Biomass and lipid production by the native green microalgaeFrontiers in bioengineering and biotechnology · 2023Article
- Development of Microalgae Biodiesel: Current Status and Perspectives.Microorganisms · 2022Review
- Development of a stable semi-continuous lipid production system of an oleaginous Chlamydomonas sp. mutant using multi-omics profiling.Biotechnology for biofuels and bioproducts · 2022Article
- Emerging Trends in Genetic Engineering of Microalgae for Commercial Applications.Marine drugs · 2022Review
- Comparative Proteomics Reveals Evidence of Enhanced EPA Trafficking in a Mutant Strain ofFrontiers in bioengineering and biotechnology · 2022Article
- Enhanced β-carotene and Biomass Production by Induced Mixotrophy inMetabolites · 2021Article
- Deciphering role of technical bioprocess parameters for bioethanol production using microalgae.Saudi journal of biological sciences · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rising oil prices and concerns over climate change have resulted in more emphasis on research into renewable biofuels from microalgae. Unlike plants, green microalgae have higher biomass productivity, will not compete with food and agriculture, and do not require fertile land for cultivation. However, microalgae biofuels currently suffer from high capital and operating costs due to low yields and costly extraction methods. Microalgae grown under optimal conditions produce large amounts of biomass but with low neutral lipid content, while microalgae grown in nutrient starvation accumulate high levels of neutral lipids but are slow growing. Producing lipids while maintaining high growth rates is vital for biofuel production because high biomass productivity increases yield per harvest volume while high lipid content decreases the cost of extraction per unit product. Therefore, there is a need for metabolic engineering of microalgae to constitutively produce high amounts of lipids without sacrificing growth. Substrate availability is a rate-limiting step in balancing growth and fatty acid (FA) production because both biomass and FA synthesis pathways compete for the same substrates, namely acetyl-CoA and NADPH. In this review, we discuss the efforts made for improving biofuel production in plants and microorganisms, the challenges faced in achieving lipid productivity, and the important role of precursor supply for FA synthesis. The main focus is placed on the enzymes which catalyzed the reactions supplying acetyl-CoA and NADPH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.