Evidence map›Paper›PMID 27895634›Full record

ArticleFrontiers in microbiology2016

Cytosolic Proteome Profiling of Aminoglycosides Resistant

Divakar Sharma, Manju Lata, Rananjay Singh, Nirmala Deo, Krishnamurthy Venkatesan, Deepa Bisht

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Understanding bacterial biofilms: From definition to treatment strategies.Frontiers in cellular and infection microbiology · 2023
    Pooled it
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  9. Identification of Potential Binders ofFrontiers in molecular biosciences · 2021
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  10. Review
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  13. Antibiotics versus biofilm: an emerging battleground in microbial communities.Antimicrobial resistance and infection control · 2019
    Review
  14. Review
  15. Cure of tuberculosis using nanotechnology: An overview.Journal of microbiology (Seoul, Korea) · 2018
    Review
  16. Frontiers in microbiology · 2017
    Article
  17. Article
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  19. Role of Bacterioferritin & Ferritin inFrontiers in cellular and infection microbiology · 2017
    Article
  20. Comparative Proteomics Analysis of Human Macrophages Infected with VirulentFrontiers in cellular and infection microbiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Divakar SharmaDepartment of Biochemistry, National JALMA Institute for Leprosy and Other Mycobacterial Diseases Agra, India.
Manju LataDepartment of Biochemistry, National JALMA Institute for Leprosy and Other Mycobacterial Diseases Agra, India.
Rananjay SinghDepartment of Biochemistry, National JALMA Institute for Leprosy and Other Mycobacterial Diseases Agra, India.
Nirmala DeoDepartment of Biochemistry, National JALMA Institute for Leprosy and Other Mycobacterial Diseases Agra, India.
Krishnamurthy VenkatesanDepartment of Biochemistry, National JALMA Institute for Leprosy and Other Mycobacterial Diseases Agra, India.
Deepa BishtDepartment of Biochemistry, National JALMA Institute for Leprosy and Other Mycobacterial Diseases Agra, India.
National JALMA Institute for Leprosy & Other Mycobacterial Diseases · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emergence of extensively drug resistant tuberculosis (XDR-TB) is the consequence of the failure of second line TB treatment. Aminoglycosides are the important second line anti-TB drugs used to treat the multi drug resistant tuberculosis (MDR-TB). Main known mechanism of action of aminoglycosides is to inhibit the protein synthesis by inhibiting the normal functioning of ribosome. Primary target of aminoglycosides are the ribosomal RNA and its associated proteins. Various mechanisms have been proposed for aminoglycosides resistance but still some are unsolved. As proteins are involved in most of the biological processes, these act as a potential diagnostic markers and drug targets. In the present study we analyzed the purely cytosolic proteome of amikacin (AK) and kanamycin (KM) resistant

Indexed as

amikacinbioinformatic toolscytosolic proteomekanamycinMycobacterium tuberculosisresistance

Identifiers

PMID27895634
PMCPMC5108770
OpenAlexW2553034306

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.