ReviewFrontiers in microbiology2016
Molecular Approaches to Screen Bioactive Compounds from Endophytic Fungi.
Review in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Diversity of Endophytic Fungi in Theobroma grandiflorum and their Potential for Biological Control of Witches' Broom Disease and Promotion of Cupuaçu Seedling Growth in the Amazon.Current microbiology · 2026Article
- Diversity and epimedium biotransformation potential of cultivable endophytic fungi associated with Epimedium brevicornum Maxim in the Qinling Mountains, China.Microbial cell factories · 2025Article
- Endophytic fungi as a potential source of anti-cancer drug.Archives of microbiology · 2024Review
- Health-Promoting Effects of Bioactive Compounds from Plant Endophytic Fungi.Journal of fungi (Basel, Switzerland) · 2023Review
- Insights into Taxol® biosynthesis by endophytic fungi.Applied microbiology and biotechnology · 2023Review
- Endophytic fungi: a potential source for drugs against central nervous system disorders.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Review
- Production, bioprocessing and antiproliferative activity of camptothecin from Aspergillus terreus, endophyte of Cinnamomum camphora: restoring their biosynthesis by indigenous microbiome of C. camphora.Microbial cell factories · 2023Article
- Endophytic Penicillium species secretes mycophenolic acid that inhibits the growth of phytopathogenic fungi.Microbial biotechnology · 2023Article
- Plants as the Extended Phenotype of Endophytes-The Actual Source of Bioactive Compounds.International journal of molecular sciences · 2023Review
- Methods used for the study of endophytic fungi: a review on methodologies and challenges, and associated tips.Archives of microbiology · 2022Review
- Insights into taxonomic diversity and bioprospecting potential of Cerrado endophytic fungi: a review exploring an unique Brazilian biome and methodological limitations.World journal of microbiology & biotechnology · 2022Review
- Interactive Effects of Filamentous Fungi and Cucurbitacin Phytonematicide on Growth of Cowpea and Suppression ofFrontiers in microbiology · 2022Article
- Diversity and Ginsenoside Biotransformation Potential of Cultivable Endophytic Fungi Associated WithFrontiers in pharmacology · 2022Article
- Biotransformation ability of endophytic fungi: from species evolution to industrial applications.Applied microbiology and biotechnology · 2021Review
- Exploiting endophytic microbes as micro-factories for plant secondary metabolite production.Applied microbiology and biotechnology · 2021Review
- Trends and Applications of Omics Technologies to Functional Characterisation of Enzymes and Protein Metabolites Produced by Fungi.Journal of fungi (Basel, Switzerland) · 2021Review
- Triggering the biosynthetic machinery of Taxol by Aspergillus flavipes via cocultivation with Bacillus subtilis: proteomic analyses emphasize the chromatin remodeling upon fungal-bacterial interaction.Environmental science and pollution research international · 2021Article
- Production, bioprocess optimization and γ-irradiation ofBiotechnology reports (Amsterdam, Netherlands) · 2021Article
- A Technical System for the Large-Scale Application of Metabolites FromFrontiers in bioengineering and biotechnology · 2021Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
Endophytic fungi are capable of producing plant associated metabolites and their analogs with therapeutic value. In order to identify the potential endophytic isolates producing bioactive compounds, one need to screen all isolated endophytes, which may run into hundreds. Isolation of endophytic fungi is relatively a simple process; but screening of the isolated fungi for required metabolite production is a cumbersome process. Endophytic fungi producing plant associated metabolites may contain genes involved in the entire biosynthetic pathway(s). Therefore, ascertaining the presence of key enzymes of a particular biosynthetic pathway could serve as a molecular marker for screening of these endophytes to produce that metabolite. In absence of entire biosynthetic pathways in endophytic fungi, plant genes associated with that metabolic pathway could serve as markers. This review focuses on the impact of molecular approaches to screen the endophytic fungi for the production of bioactive compounds. An attempt has been made on screening of anticancer compounds like taxol (paclitaxel), podophyllotoxin, and camptothecin using molecular markers. The advantages of molecular approaches over conventional methods to screen endophytic fungi and also identification of endophytic fungi are discussed.
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