ArticleFrontiers in endocrinology2016
Serum Zn/Cu Ratio Is Associated with Renal Function, Glycemic Control, and Metabolic Parameters in Japanese Patients with and without Type 2 Diabetes: A Cross-sectional Study.
Article in Frontiers in endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 46 citations in OpenAlex.
- Machine Learning-Based Biomarker Discovery from Serum Trace Elements and Biochemical Parameters in Patients with Nasal Polyps.Biological trace element research · 2026Article
- Serum copper modulates cognitive function in diabetic patients via an HDL-C-mediated pathway: identification of a 25 µg/dL exploratory threshold.Diabetology & metabolic syndrome · 2025Article
- Article
- Study of plasma essential element concentrations to explore markers of acute myocardial infarction.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Association of Trace Elements with Polycystic Ovary Syndrome in Women-A Case-Control Study.Metabolites · 2025Article
- Article
- Association of plasma zinc and copper levels with mild cognitive impairment in patients with type 2 diabetes.Frontiers in nutrition · 2025Article
- Oxidative balance score is associated with the risk of diabetic kidney disease in patients with type 2 diabetes mellitus: evidence from NHANES 2007-2018.Frontiers in nutrition · 2024Article
- Further Evidence on Trace Element Imbalances in Haemodialysis Patients-Paired Analysis of Blood and Serum Samples.Nutrients · 2023Article
- Potential Role of Copper in Diabetes and Diabetic Kidney Disease.Metabolites · 2022Review
- Influence of zinc levels and Nrf2 expression in the clinical and pathological changes in patients with diabetic nephropathy.Nutrition & diabetes · 2022Article
- Evaluation of Serum Trace Element Levels and Biochemical Parameters of COVID-19 Patients According to Disease Severity.Biological trace element research · 2022Article
- Magnesium Status and Calcium/Magnesium Ratios in a Series of Cystic Fibrosis Patients.Nutrients · 2022Article
- Synergistic association of the copper/zinc ratio under inflammatory conditions with diabetic kidney disease in patients with type 2 diabetes: The Asahi Diabetes Complications Study.Journal of diabetes investigation · 2022Article
- Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study.Nutrients · 2021Article
- The Association between Zinc and Copper Circulating Levels and Cardiometabolic Risk Factors in Adults: A Study of Qatar Biobank Data.Nutrients · 2021Article
- Study on Reference Range of Zinc, Copper and Copper/Zinc Ratio in Childbearing Women of China.Nutrients · 2021Article
- Proanthocyanidins Protect Against Cadmium-Induced Diabetic Nephropathy Through p38 MAPK and Keap1/Nrf2 Signaling Pathways.Frontiers in pharmacology · 2021Article
- Serum zinc concentrations and characteristics of zinc deficiency/marginal deficiency among Japanese subjects.Journal of general and family medicine · 2020Article
- Copper-zinc imbalance induces kidney tubule damage and oxidative stress in a population exposed to chronic environmental cadmium.International archives of occupational and environmental health · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundZinc (Zn) and copper (Cu) may play a pivotal role in the pathogenesis of diabetes and diabetic complications by mediating oxidative stress. Both Zn deficiency and excess of Cu are associated with an increased risk of type 2 diabetes and cardiovascular disease. We aimed to investigate the relationships between serum Zn/Cu ratio and glycemic status, renal function, and metabolic parameters in patients with and without type 2 diabetes.
methodsWe conducted a cross-sectional study on 355 subjects (149 type 2 diabetic and 206 non-diabetic) in whom serum Zn and Cu levels were measured at the same time. Associations between serum Zn/Cu ratio and clinical data were evaluated using multiple regression analysis. We also evaluated associations between serum Zn/Cu ratio and the prevalence of type 2 diabetes and glycemic control by multivariate logistic regression analysis.
resultsSerum Zn/Cu ratio was positively associated with estimated glomerular filtration rate after adjustment for body mass index (BMI) (β = 0.137,
conclusionSerum Zn/Cu ratio was favorably associated with renal function in all subjects and glycemic control in patients with type 2 diabetes. The Zn/Cu ratio, in addition to the individual serum levels of trace elements, is important for metabolism in humans.
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