Evidence map›Paper›PMID 27895577›Full record

ArticleFrontiers in aging neuroscience2016

Fus1 KO Mouse As a Model of Oxidative Stress-Mediated Sporadic Alzheimer's Disease: Circadian Disruption and Long-Term Spatial and Olfactory Memory Impairments.

Guillermo Coronas-Samano, Keeley L Baker, Winston J T Tan, Alla V Ivanova, Justus V Verhagen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Guillermo Coronas-SamanoThe John B. Pierce Laboratory New Haven, CT, USA.
Keeley L BakerThe John B. Pierce LaboratoryNew Haven, CT, USA; Department of Neuroscience, Yale University School of MedicineNew Haven, CT, USA.
Winston J T TanDepartment of Surgery, Yale University School of Medicine New Haven, CT, USA.
Alla V IvanovaDepartment of Surgery, Yale University School of Medicine New Haven, CT, USA.
Justus V VerhagenThe John B. Pierce LaboratoryNew Haven, CT, USA; Department of Neuroscience, Yale University School of MedicineNew Haven, CT, USA.
Yale University · USJohn B. Pierce Laboratory · US

Funding

Multimodal flavor integration and retronasal olfaction in the mouseR01DC014723 · NIDCD · JOHN B. PIERCE LABORATORY, INC. · PI VERHAGEN, JUSTUS V. · 2016 to 2020
$2.4M
NIDCD NIH HHS R01 DC014723
6 · The paper itself

Abstract

Insufficient advances in the development of effective therapeutic treatments of sporadic Alzheimer's Disease (sAD) to date are largely due to the lack of sAD-relevant animal models. While the vast majority of models do recapitulate AD's hallmarks of plaques and tangles by virtue of tau and/or beta amyloid overexpression, these models do not reflect the fact that in sAD (unlike familial AD) these genes are not risk factors

Indexed as

Fus1 KOFus1/Tusc2hippocampusMorris water mazeolfactionolfactory bulboxidative stresssporadic Alzheimer's Disease

Identifiers

PMID27895577
PMCPMC5108791
OpenAlexW2556743973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.