Evidence map›Paper›PMID 27895567›Full record

ArticleFrontiers in human neuroscience2016

Cognitive Processing in Non-Communicative Patients: What Can Event-Related Potentials Tell Us?

Zulay R Lugo, Lucia R Quitadamo, Luigi Bianchi, Fréderic Pellas, Sandra Veser, Damien Lesenfants, Ruben G L Real, Cornelia Herbert, Christoph Guger, Boris Kotchoubey and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 7 countries.

Zulay R LugoComa Science Group, University and University Hospital of Liège, GIGALiège, Belgium; Institute of Psychology, University of WürzburgWürzburg, Germany; French Association of Locked-in Syndrome (ALIS)Paris, France.
Lucia R QuitadamoNeuroelectrical Imaging and BCI Laboratory, Fondazione Santa Lucia, IRCCSRome, Italy; School of Life and Health Sciences, Aston Brain Centre, Aston UniversityBirmingham, UK.
Luigi BianchiDepartment of Civil Engineering and Computer Science, University of Rome Tor Vergata Rome, Italy.
Fréderic PellasFrench Association of Locked-in Syndrome (ALIS)Paris, France; Coma Arousal Unit - PMR Department, Nîmes University HospitalNîmes, France.
Sandra VeserInstitute for Medical Psychology and Behavioural Neurobiology, University of Tübingen Tübingen, Germany.
Damien LesenfantsComa Science Group, University and University Hospital of Liège, GIGA Liège, Belgium.
Ruben G L RealInstitute of Psychology, University of Würzburg Würzburg, Germany.
Cornelia HerbertInstitute of Psychology, University of WürzburgWürzburg, Germany; Department of Psychiatry, University of TübingenTübingen, Germany; Department of Biomedical Resonance, University of TübingenTübingen, Germany.
Christoph GugerG.Tec Medical Engineering GmbH/Guger Technologies OG Graz, Austria.
Boris KotchoubeyInstitute for Medical Psychology and Behavioural Neurobiology, University of Tübingen Tübingen, Germany.
Donatella MattiaNeuroelectrical Imaging and BCI Laboratory, Fondazione Santa Lucia, IRCCS Rome, Italy.
Andrea KüblerInstitute of Psychology, University of Würzburg Würzburg, Germany.
Steven LaureysComa Science Group, University and University Hospital of Liège, GIGA Liège, Belgium.
Quentin NoirhommeComa Science Group, University and University Hospital of Liège, GIGALiège, Belgium; Department of Cognitive Neuroscience, Maastricht UniversityMaastricht, Netherlands; Brain Innovation B.V.Maastricht, Netherlands.
University of Tübingen · DEUniversity of Würzburg · DEIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Liège · BEGuger Technologies (Austria) · ATMaastricht University · NLUniversité de Nîmes · FRUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Event-related potentials (ERP) have been proposed to improve the differential diagnosis of non-responsive patients. We investigated the potential of the P300 as a reliable marker of conscious processing in patients with locked-in syndrome (LIS). Eleven chronic LIS patients and 10 healthy subjects (HS) listened to a complex-tone auditory oddball paradigm, first in a passive condition (listen to the sounds) and then in an active condition (counting the deviant tones). Seven out of nine HS displayed a P300 waveform in the passive condition and all in the active condition. HS showed statistically significant changes in peak and area amplitude between conditions. Three out of seven LIS patients showed the P3 waveform in the passive condition and five of seven in the active condition. No changes in peak amplitude and only a significant difference at one electrode in area amplitude were observed in this group between conditions. We conclude that, in spite of keeping full consciousness and intact or nearly intact cortical functions, compared to HS, LIS patients present less reliable results when testing with ERP, specifically in the passive condition. We thus strongly recommend applying ERP paradigms in an active condition when evaluating consciousness in non-responsive patients.

Indexed as

event-related potentialslocked-in syndromeminimally conscious stateP300unresponsive wakefulness syndromevegetative state

Identifiers

PMID27895567
PMCPMC5107572
OpenAlexW2554360913

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.