ArticleFrontiers in neuroscience2016
Closed-Loop Task Difficulty Adaptation during Virtual Reality Reach-to-Grasp Training Assisted with an Exoskeleton for Stroke Rehabilitation.
Article in Frontiers in neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- On the correlation between training modalities and recovery stages in poststroke robotic rehabilitation of the upper limb: a systematic review.Journal of neuroengineering and rehabilitation · 2026Pooled it
- Analysis of the Factors Related to the Effectiveness of Transcranial Current Stimulation in Upper Limb Motor Function Recovery after Stroke: a Systematic Review.Journal of medical systems · 2019Pooled it
- Motor imagery-based brain-computer interface rehabilitation programs enhance upper extremity performance and cortical activation in stroke patients.Journal of neuroengineering and rehabilitation · 2024Trial
- Effectiveness of a combined transcranial direct current stimulation and virtual reality-based intervention on upper limb function in chronic individuals post-stroke with persistent severe hemiparesis: a randomized controlled trial.Journal of neuroengineering and rehabilitation · 2021Trial
- Boosting robot-assisted rehabilitation of stroke hemiparesis by individualized selection of upper limb movements - a pilot study.Journal of neuroengineering and rehabilitation · 2019Trial
- Using an upper extremity exoskeleton for semi-autonomous exercise during inpatient neurological rehabilitation- a pilot study.Journal of neuroengineering and rehabilitation · 2018Trial
- OpenOR - a virtual reality framework for medical education.Acta neurochirurgica · 2026Article
- Robot-Assisted Gravity Compensation for Upper Limb Motor Rehabilitation: A Systematic Review.Bioengineering (Basel, Switzerland) · 2026Review
- Machine learning-based adaptive personalization in virtual reality stroke rehabilitation: a systematic review.Frontiers in rehabilitation sciences · 2026Review
- A Virtual reality-based System for Hand Rehabilitation and Its Impact on the Emotional and Physiological Responses of Users.Basic and clinical neuroscience · 2025Article
- Effective Motor Skill Learning Induces Inverted-U Load-Dependent Activation in Contralateral Pre-Motor and Supplementary Motor Area.Human brain mapping · 2025Article
- Normal aging affects unconstrained three-dimensional reaching against gravity with reduced vertical precision and increased co-contraction: a pilot study.Experimental brain research · 2022Article
- The impact of visuospatial perception on distance judgment and depth perception in an Augmented Reality environment in patients after stroke: an exploratory study.Journal of neuroengineering and rehabilitation · 2021Observational
- Clinical validation of kinematic assessments of post-stroke upper limb movements with a multi-joint arm exoskeleton.Journal of neuroengineering and rehabilitation · 2021Article
- Virtual Reality in the Neurosciences: Current Practice and Future Directions.Frontiers in surgery · 2021Review
- Flexible Virtual Reality System for Neurorehabilitation and Quality of Life Improvement.Sensors (Basel, Switzerland) · 2020Article
- Motor improvement estimation and task adaptation for personalized robot-aided therapy: a feasibility study.Biomedical engineering online · 2020Article
- Brain-Machine Neurofeedback: Robotics or Electrical Stimulation?Frontiers in bioengineering and biotechnology · 2020Article
- A Review of Virtual Coaching Systems in Healthcare: Closing the Loop With Real-Time Feedback.Frontiers in digital health · 2020Review
- Exoskeletons With Virtual Reality, Augmented Reality, and Gamification for Stroke Patients' Rehabilitation: Systematic Review.JMIR rehabilitation and assistive technologies · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke patients with severe motor deficits of the upper extremity may practice rehabilitation exercises with the assistance of a multi-joint exoskeleton. Although this technology enables intensive task-oriented training, it may also lead to slacking when the assistance is too supportive. Preserving the engagement of the patients while providing "assistance-as-needed" during the exercises, therefore remains an ongoing challenge. We applied a commercially available seven degree-of-freedom arm exoskeleton to provide passive gravity compensation during task-oriented training in a virtual environment. During this 4-week pilot study, five severely affected chronic stroke patients performed reach-to-grasp exercises resembling activities of daily living. The subjects received virtual reality feedback from their three-dimensional movements. The level of difficulty for the exercise was adjusted by a performance-dependent real-time adaptation algorithm. The goal of this algorithm was the automated improvement of the range of motion. In the course of 20 training and feedback sessions, this unsupervised adaptive training concept led to a progressive increase of the virtual training space (
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Registered trials
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