ArticleJournal of pain research2016
Effects of fentanyl on pain and motor behaviors following a collagenase-induced intracerebral hemorrhage in rats.
Article in Journal of pain research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Grimace scale, burrowing, and nest building for the assessment of post-surgical pain in mice and rats-A systematic review.Frontiers in veterinary science · 2022Pooled it
- The grimace scale: a useful tool for assessing pain in laboratory animals.Experimental animals · 2024Review
- White and gray matter integrity evaluated by MRI-DTI can serve as noninvasive and reliable indicators of structural and functional alterations in chronic neurotrauma.Scientific reports · 2024Article
- The effect of thioredoxin-1 in a rat model of traumatic brain injury depending on diurnal variation.Brain and behavior · 2023Article
- Grimace Scores: Tools to Support the Identification of Pain in Mammals Used in Research.Animals : an open access journal from MDPI · 2020Review
- Activation of PPAR-β/δ Attenuates Brain Injury by Suppressing Inflammation and Apoptosis in a Collagenase-Induced Intracerebral Hemorrhage Mouse Model.Neurochemical research · 2020Article
- Use of the Rat Grimace Scale to Evaluate Visceral Pain in a Model of Chemotherapy-Induced Mucositis.Animals : an open access journal from MDPI · 2019Article
- Blast-induced brain injury in rats leads to transient vestibulomotor deficits and persistent orofacial pain.Brain injury · 2018Article
- In search of a rodent model of placebo analgesia in chronic orofacial neuropathic pain.Neurobiology of pain (Cambridge, Mass.)Article
- Safety and Efficacy of Ketamine Versus Ketamine-Fentanyl-Dexmedetomidine Combination for Anesthesia and Analgesia in Rats.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIntracerebral hemorrhage (IH) and cephalalgia are common consequences of traumatic brain injury. One of the primary obstacles for patient recovery is the paucity of treatments to support an appropriate analgesic protocol. The present study aimed to assess pain and motor behaviors following different doses of fentanyl on a rat model of IH.
methodsTwenty-one male Sprague Dawley rats underwent a stereotaxic surgery to produce a collagenase-induced IH in the right caudoputamen nucleus. The control group (n=6) received saline subcutaneously (SC), and experimental groups received either 5 (n=6), 10 (n=6), or 20 (n=3) µg/kg of fentanyl SC, 2 hours following surgery and on 2 subsequent days. Only 3 animals received 20 µg/kg because this dose caused catalepsy for 15-20 minutes following the injection. The rat grimace scale, a neurological examination, balance beam test, and rotarod test were performed for 5 consecutive days postoperatively to evaluate pain and motor performance. At the end of the experimentation, the brains were evaluated to determine hematoma volume, and the number of reactive astrocytes and necrotic neurons.
resultsWhen compared to controls, the grimace scale showed that 5 µg/kg fentanyl significantly alleviated pain on day 2 only (
conclusionFentanyl, at a dose of 10 µg/kg SC, provides substantial analgesia following a collagenase-induced IH in rats; however, it can alter motor performance following analgesic treatments.
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