Evidence map›Paper›PMID 27895479›Full record

ArticleInternational journal of nanomedicine

Cationic PEGylated liposomes incorporating an antimicrobial peptide tilapia hepcidin 2-3: an adjuvant of epirubicin to overcome multidrug resistance in cervical cancer cells.

Vivian Juang, Hsin-Pin Lee, Anya Maan-Yuh Lin, Yu-Li Lo

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Vivian JuangDepartment and Institute of Pharmacology, National Yang-Ming University.
Hsin-Pin LeeDepartment of Biological Sciences and Technology, National University of Tainan.
Anya Maan-Yuh LinDepartment and Institute of Pharmacology, National Yang-Ming University; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China.
Yu-Li LoDepartment and Institute of Pharmacology, National Yang-Ming University.
National University of Tainan · TWInstitute of Pharmacology · CZNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) have been recently evaluated as a new generation of adjuvants in cancer chemotherapy. In this study, we designed PEGylated liposomes encapsulating epirubicin as an antineoplastic agent and tilapia hepcidin 2-3, an AMP, as a multidrug resistance (MDR) transporter suppressor and an apoptosis/autophagy modulator in human cervical cancer HeLa cells. Cotreatment of HeLa cells with PEGylated liposomal formulation of epirubicin and hepcidin 2-3 significantly increased the cytotoxicity of epirubicin. The liposomal formulations of epirubicin and/or hepcidin 2-3 were found to noticeably escalate the intracellular H

Indexed as

Adjuvants, ImmunologicAnimalsAnti-Infective AgentsAntimicrobial Cationic PeptidesApoptosisATP-Binding Cassette, Sub-Family C ProteinsATP Binding Cassette Transporter, Subfamily BCaspase 3Caspase 9Cell CycleCell SurvivalDrug Resistance, MultipleDrug Resistance, NeoplasmEpirubicinEpithelial-Mesenchymal TransitionFemaleABCB1 protein, humanABCC2 protein, humanAdjuvants, ImmunologicAnti-Infective AgentsAntimicrobial Cationic PeptidesATP-Binding Cassette, Sub-Family C ProteinsATP Binding Cassette Transporter, Subfamily BCASP3 protein, humanCASP9 protein, humanCaspase 3Caspase 9EpirubicinHepcidinsLiposomesmultidrug resistance-associated protein 1Multidrug Resistance-Associated Protein 2Reactive Oxygen Speciesantimicrobial peptideapoptosisautophagyepirubicinliposomesmultidrug resistance

Identifiers

PMID27895479
PMCPMC5117904
OpenAlexW2554026175

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.