ArticleWorld journal of gastroenterology2016
Lymphovascular invasion in more than one-quarter of small rectal neuroendocrine tumors.
Article in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Rectal neuroendocrine tumors: Update.World journal of gastrointestinal oncology · 2026Review
- Efficacy, Safety and Oncological Outcomes of Minimally Invasive Approaches (EMR, ESD and TAMIS) for Early Rectal Tumors: A Systematic Review and Meta-Analysis.Medical devices (Auckland, N.Z.) · 2026Review
- Current status of endoscopic resection for small rectal neuroendocrine tumors.World journal of gastroenterology · 2025Review
- Recurrence pattern and mapping of lymph node metastases from rectal neuroendocrine tumors.International journal of colorectal disease · 2025Article
- Primary small rectal neuroendocrine tumor with pelvic lateral lymph nodes metastasis: A case report and review of literature.International journal of surgery case reports · 2025Article
- The Association Between Venous Invasion and Distant Metastasis in Head and Neck Squamous Cell Carcinoma.Cureus · 2025Article
- Review
- Small Cell Carcinoma of the Rectum Associated With a Tubulovillous Adenoma: An Atypical Case Presentation.Cureus · 2024Article
- Clinical outcomes and risk factors associated with poor prognosis after endoscopic resection of 10-20 mm rectal neuroendocrine tumors: a multicenter, retrospective study of 10-year experience.Surgical endoscopy · 2023Article
- Different miRNAs Related toInternational journal of molecular sciences · 2023Article
- Endoscopic treatment and management of rectal neuroendocrine tumors less than 10 mm in diameter.World journal of gastrointestinal endoscopy · 2023Review
- Is lymphatic invasion of microrectal neuroendocrine tumors an incidental event?: A case report.World journal of clinical cases · 2023Article
- Risk Factors for Lymph Node Metastasis and Oncologic Outcomes in Small Rectal Neuroendocrine Tumors with Lymphovascular Invasion.Gut and liver · 2022Article
- Assessment of the Risk of Nodal Involvement in Rectal Neuroendocrine Neoplasms: The NOVARA Score, a Multicentre Retrospective Study.Journal of clinical medicine · 2022Article
- Endoscopic resection using an over-the-scope clip for duodenal neuroendocrine tumors.Endoscopy international open · 2021Article
- A nationwide, multi-institutional collaborative retrospective study of colorectal neuroendocrine tumors in Japan.Annals of gastroenterological surgery · 2021Article
- Clinical outcomes of endoscopic mucosal resection for rectal neuroendocrine tumor.BMC gastroenterology · 2018Article
- Identification of Phosphohistone H3 Cutoff Values Corresponding to Original WHO Grades but Distinguishable in Well-Differentiated Gastrointestinal Neuroendocrine Tumors.BioMed research international · 2018Article
- Risk factors associated with the progression and metastases of hindgut neuroendocrine tumors: a retrospective study.BMC cancer · 2017Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo identify the frequency, clinicopathological risk factors, and prognostic significance of lymphovascular invasion (LVI) in endoscopically resected small rectal neuroendocrine tumors (NETs).
methodsBetween June 2005 and December 2015, 104 cases of endoscopically resected small (≤ 1 cm) rectal NET specimens at Hallym University Sacred Heart Hospital in Korea were retrospectively evaluated. We compared the detected rate of LVI in small rectal NET specimens by two methods: hematoxylin and eosin (H&E) and ancillary immunohistochemical staining (D2-40 and Elastica van Gieson); in addition, LVI detection rate difference between endoscopic procedures were also evaluated. Patient characteristics, prognosis and endoscopic resection results were reviewed by medical charts.
resultsWe observed LVI rates of 25.0% and 27.9% through H&E and ancillary immunohistochemical staining. The concordance rate between H&E and ancillary studies was 81.7% for detection of LVI, which showed statistically strong agreement between two methods (κ = 0.531,
conclusionLVI may be present in a high percentage of small rectal NETs, which may not be associated with short-term prognosis.
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