Evidence map›Paper›PMID 27895399›Full record

ArticleWorld journal of gastroenterology2016

Altered pattern of tumor necrosis factor-alpha production in peripheral blood monocytes from Crohn's disease.

Claudia Loganes, Alessia Pin, Samuele Naviglio, Martina Girardelli, Anna Monica Bianco, Stefano Martelossi, Alberto Tommasini, Elisa Piscianz

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Claudia LoganesClaudia Loganes, Samuele Naviglio, Elisa Piscianz, Department of Medicine, Surgery and Health Sciences, University of Trieste, 34128 Trieste, Italy.
Alessia PinClaudia Loganes, Samuele Naviglio, Elisa Piscianz, Department of Medicine, Surgery and Health Sciences, University of Trieste, 34128 Trieste, Italy.
Samuele NaviglioClaudia Loganes, Samuele Naviglio, Elisa Piscianz, Department of Medicine, Surgery and Health Sciences, University of Trieste, 34128 Trieste, Italy.
Martina GirardelliClaudia Loganes, Samuele Naviglio, Elisa Piscianz, Department of Medicine, Surgery and Health Sciences, University of Trieste, 34128 Trieste, Italy.
Anna Monica BiancoClaudia Loganes, Samuele Naviglio, Elisa Piscianz, Department of Medicine, Surgery and Health Sciences, University of Trieste, 34128 Trieste, Italy.
Stefano MartelossiClaudia Loganes, Samuele Naviglio, Elisa Piscianz, Department of Medicine, Surgery and Health Sciences, University of Trieste, 34128 Trieste, Italy.
Alberto TommasiniClaudia Loganes, Samuele Naviglio, Elisa Piscianz, Department of Medicine, Surgery and Health Sciences, University of Trieste, 34128 Trieste, Italy.
Elisa PiscianzClaudia Loganes, Samuele Naviglio, Elisa Piscianz, Department of Medicine, Surgery and Health Sciences, University of Trieste, 34128 Trieste, Italy.
Pediatrics and Genetics · USUniversity of Trieste · ITIRCCS Materno Infantile Burlo Garofolo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the inflammatory state in Crohn's disease (CD) patients and correlate it with genetic background and microbial spreading.

methodsBy means of flow cytometry, production of tumor necrosis factor-alpha (TNF-α) was measured in peripheral blood monocytes from patients suffering from CD, ulcerative colitis (UC) and in healthy subjects after stimulation of the NOD2 and TLR pathways. CD patients were genotyped for the three most common

resultsThe patients with CD were characterized by a significantly higher monocyte basal expression of TNF-α compared with healthy subjects and UC patients, and after stimulation with Pam

conclusionPeripheral monocytes from CD express higher basal and stimulated TNF-α than controls, regardless of

Indexed as

Acute-Phase ProteinsAdolescentBiomarkersCarrier ProteinsCase-Control StudiesCells, CulturedChildColitis, UlcerativeCrohn DiseaseFemaleGenetic Predisposition to DiseaseGenetic VariationHumansImmunity, InnateInflammation MediatorsLeukocytes, MononuclearAcute-Phase ProteinsBiomarkersCarrier ProteinsInflammation MediatorsLipopolysaccharide-Binding ProteinLipopolysaccharide ReceptorsMembrane GlycoproteinsNOD2 protein, humanNod2 Signaling Adaptor ProteinTumor Necrosis Factor-alphaActivity indexCrohn’s diseaseDysbiosisLPS-binding proteinNOD2 variantsToll like receptorsTumor necrosis factor-αUlcerative colitis

Identifiers

PMID27895399
PMCPMC5107593
OpenAlexW2548723801

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.