ReviewInternational journal of immunopathology and pharmacology2016
Sudden sensorineural hearing loss: Is there a connection with inner ear electrolytic disorders? A literature review.
Review in International journal of immunopathology and pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- The relationship between SGLT2 inhibitors and hearing loss: a nationwide population-based retrospective cohort study.Diabetology & metabolic syndrome · 2025Article
- The genetic susceptibility of SOD2 gene polymorphism in sudden sensorineural hearing loss (SSNHL).Global medical genetics · 2025Article
- Assessment of Peripheral and Central Auditory Processing after Treatment for Idiopathic Sudden Sensorineural Hearing Loss.International archives of otorhinolaryngology · 2024Article
- Effectiveness of Various Treatments for Sudden Sensorineural Hearing Loss-A Retrospective Study.Life (Basel, Switzerland) · 2022Article
- Comparison of Sudden Sensorineural Hearing Loss with Tinnitus and Short-Term Tinnitus.Neural plasticity · 2021Article
- Article
- Is Cyclosporine Ototoxic?Frontiers in neurology · 2020Article
- Endolymphatic hydrops and ionic transporters: genetic and biohumoral aspects.Journal of neurology · 2019Review
- Intracochlear administration of steroids with a catheter during human cochlear implantation: a safety and feasibility study.Drug delivery and translational research · 2018Article
- Gender differences in audio-vestibular disorders.International journal of immunopathology and pharmacologyReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrolytic disorders of the inner ear represent a model that could be implicated in partially explaining the pathogenesis of sudden sensorineural hearing loss (SSNHL). Different types of electrolytes and different inner-ear loci are involved in cochlear homeostasis physiologically, to ensure the maintenance of an ion-balanced cochlear environment allowing a normal hair cell function. It has been hypothesized that a sudden loss of endocochlear potential, due to a rapid disruption of the inner ear fluid osmolality, could be responsible for a deterioration of the hearing function caused by damaged hair cells. The aim of this paper was to review the current literature and identify sources which might validate/fortify the hypothesis that inner ear electrolytic disorders have a role in the etiopathogenesis of SSNHL. The data in the literature underline the importance of ionic homeostasis in the inner ear, but they do not support a direct link between SSNHL and electrolyte disorders/imbalances. There is marginal evidence from otoacoustic emissions research that an indirect link might be present.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.