Evidence map›Paper›PMID 27895190›Full record

ArticleHypertension (Dallas, Tex. : 1979)2017

Caveolin-1 Deletion Prevents Hypertensive Vascular Remodeling Induced by Angiotensin II.

Steven J Forrester, Katherine J Elliott, Tatsuo Kawai, Takashi Obama, Michael J Boyer, Kyle J Preston, Zhen Yan, Satoru Eguchi, Victor Rizzo

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Steven J ForresterFrom the Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA (S.J.F., K.J.E., T.K., T.O., M.J.B., K.J.P., S.E., V.R.); and Department of Medicine, University of Virginia, Charlottesville (Z.Y.).
Katherine J ElliottFrom the Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA (S.J.F., K.J.E., T.K., T.O., M.J.B., K.J.P., S.E., V.R.); and Department of Medicine, University of Virginia, Charlottesville (Z.Y.).
Tatsuo KawaiFrom the Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA (S.J.F., K.J.E., T.K., T.O., M.J.B., K.J.P., S.E., V.R.); and Department of Medicine, University of Virginia, Charlottesville (Z.Y.).
Takashi ObamaFrom the Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA (S.J.F., K.J.E., T.K., T.O., M.J.B., K.J.P., S.E., V.R.); and Department of Medicine, University of Virginia, Charlottesville (Z.Y.).
Michael J BoyerFrom the Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA (S.J.F., K.J.E., T.K., T.O., M.J.B., K.J.P., S.E., V.R.); and Department of Medicine, University of Virginia, Charlottesville (Z.Y.).
Kyle J PrestonFrom the Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA (S.J.F., K.J.E., T.K., T.O., M.J.B., K.J.P., S.E., V.R.); and Department of Medicine, University of Virginia, Charlottesville (Z.Y.).
Zhen YanFrom the Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA (S.J.F., K.J.E., T.K., T.O., M.J.B., K.J.P., S.E., V.R.); and Department of Medicine, University of Virginia, Charlottesville (Z.Y.).
Satoru EguchiFrom the Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA (S.J.F., K.J.E., T.K., T.O., M.J.B., K.J.P., S.E., V.R.); and Department of Medicine, University of Virginia, Charlottesville (Z.Y.).
Victor RizzoFrom the Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA (S.J.F., K.J.E., T.K., T.O., M.J.B., K.J.P., S.E., V.R.); and Department of Medicine, University of Virginia, Charlottesville (Z.Y.) rizzov@temple.edu seguchi@temple.edu.
University of Virginia · USTemple University · US

Funding

p38 MAPK a regulator of muscle contraction and functionR01AR050429 · NIAMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI YAN, ZHEN · 2005 to 2022
$5.3M
Mechanism of Hypertensive Vascular Remodeling and End-Organ DamageR01HL133248 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI EGUCHI, SATORU · 2016 to 2019
$1.8M
Vascular signal as a therapeutic target for abdominal aortic aneurysmR01HL128324 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI EGUCHI, SATORU, RIZZO, VICTOR J. · 2015 to 2018
$1.6M
The Role of Endothelial Dysfunction and Vascular Inflammation in Hypertensive Vascular RemodelingF31HL127971 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI FORRESTER, STEVEN · 2016 to 2016
$27k
NHLBI NIH HHS F31 HL127971NHLBI NIH HHS R01 HL128324NHLBI NIH HHS R01 HL133248NIAMS NIH HHS R01 AR050429
6 · The paper itself

Abstract

It has been proposed that membrane microdomains, caveolae, in vascular cells are critical for signal transduction and downstream functions induced by angiotensin II (AngII). We have tested our hypothesis that caveolin-1 (Cav1), a major structural protein of vascular caveolae, plays a critical role in the development of vascular remodeling by AngII via regulation of epidermal growth factor receptor and vascular endothelial adhesion molecule-1. Cav1

Indexed as

Gene DeletionAngiotensin IIAnimalsBlood PressureCaveolin 1Disease Models, AnimalHypertensionMaleMiceMice, Inbred C57BLMuscle, Smooth, VascularRatsRats, Sprague-DawleySignal TransductionVascular RemodelingAngiotensin IICaveolin 1angiotensin IIblood pressureendothelial cellshypertensionsignal transduction

Identifiers

PMID27895190
PMCPMC5145768
OpenAlexW2557318830

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.