Evidence map›Paper›PMID 27895120›Full record

ArticleThe Journal of biological chemistry2017

Ankyrin G Expression Regulates Apical Delivery of the Epithelial Sodium Channel (ENaC).

Christine A Klemens, Robert S Edinger, Lindsay Kightlinger, Xiaoning Liu, Michael B Butterworth

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. (R)-vanzacaftor potentiates BKAmerican journal of physiology. Cell physiology · 2025
    Article
  5. SECS, drugs, and Rac1&Rho: regulation of EnNaC in vascular endothelial cells.Pflugers Archiv : European journal of physiology · 2025
    Article
  6. Article
  7. Epithelial NaComprehensive Physiology · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Non-coding RNAs and the mineralocorticoid receptor in the kidney.Molecular and cellular endocrinology · 2021
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Physiological regulation of the epithelial NaAmerican journal of physiology. Renal physiology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Christine A KlemensFrom the Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261.
Robert S EdingerFrom the Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261.
Lindsay KightlingerFrom the Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261.
Xiaoning LiuFrom the Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261.
Michael B ButterworthFrom the Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261 michael7@pitt.edu.
University of Pittsburgh · US

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Role of MicroRNAs in Kidney Sodium RegulationR01DK102843 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BUTTERWORTH, MICHAEL B · 2015 to 2024
$3.6M
NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK102843
6 · The paper itself

Abstract

The epithelial sodium channel (ENaC) is the limiting entry point for Na

Indexed as

AnimalsAnkyrinsBiological TransportCell MembraneCells, CulturedEndocytosisEpithelial Sodium ChannelsIon TransportKidney Tubules, CollectingMiceRatsSodium-Potassium-Exchanging ATPaseAnkyrinsEpithelial Sodium ChannelsSodium-Potassium-Exchanging ATPaseAnkyrinapical transportcollecting ductdistal nephronepithelial sodium channel (ENaC)kidneymembrane traffickingsodium transportvesicles

Identifiers

PMID27895120
PMCPMC5217695
OpenAlexW2559130802

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.