Evidence map›Paper›PMID 27895069›Full record

Observational studyCirculation. Heart failure2016

Association Between Poorer Cognitive Function and Reduced Objectively Monitored Medication Adherence in Patients With Heart Failure.

Mary A Dolansky, Misty A W Hawkins, Julie T Schaefer, Abdus Sattar, John Gunstad, Joseph D Redle, Richard Josephson, Shirley M Moore, Joel W Hughes

Registry-linked trialOpen access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Circulation. Heart failure, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01461629 (Cognitive Impairment and Self-management in Adults With Heart Failure), which is not on this map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01461629 completednot on this map

Cognitive Impairment and Self-management in Adults With Heart Failure

TypeobservationalSponsorKent State UniversityRan2010Enrolled372ConditionsCognitive Impairment, Cardiac Disease, Heart Failure
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Real-world characteristics and management of ventricular tachycardias in ICD patients: Data from the VIDEO registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  7. Article
  8. Article
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  11. Review
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  13. Review
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  15. Review
  16. Article
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  19. Article
  20. Phenylketonuria as an Adherence Disease.Patient preference and adherence · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mary A DolanskyFrom the Frances Payne Bolton School of Nursing (M.A.D., A.S., S.M.M.), Department of Epidemiology & Biostatistics (A.S.), and School of Medicine (R.J.), Case Western Reserve University, Cleveland, OH; Department of Psychology, Oklahoma State University, Stillwater (M.A.W.H.); Department of Psychological Sciences, Kent State University, OH (J.T.S., J.G., J.W.H.); Cardiovascular Institute, Summa Health System, Akron City Hospital, OH (J.D.R., J.W.H.); and Harrington Heart & Vascular Institute, University Hospitals, Cleveland, OH (R.J.).
Misty A W HawkinsFrom the Frances Payne Bolton School of Nursing (M.A.D., A.S., S.M.M.), Department of Epidemiology & Biostatistics (A.S.), and School of Medicine (R.J.), Case Western Reserve University, Cleveland, OH; Department of Psychology, Oklahoma State University, Stillwater (M.A.W.H.); Department of Psychological Sciences, Kent State University, OH (J.T.S., J.G., J.W.H.); Cardiovascular Institute, Summa Health System, Akron City Hospital, OH (J.D.R., J.W.H.); and Harrington Heart & Vascular Institute, University Hospitals, Cleveland, OH (R.J.).
Julie T SchaeferFrom the Frances Payne Bolton School of Nursing (M.A.D., A.S., S.M.M.), Department of Epidemiology & Biostatistics (A.S.), and School of Medicine (R.J.), Case Western Reserve University, Cleveland, OH; Department of Psychology, Oklahoma State University, Stillwater (M.A.W.H.); Department of Psychological Sciences, Kent State University, OH (J.T.S., J.G., J.W.H.); Cardiovascular Institute, Summa Health System, Akron City Hospital, OH (J.D.R., J.W.H.); and Harrington Heart & Vascular Institute, University Hospitals, Cleveland, OH (R.J.).
Abdus SattarFrom the Frances Payne Bolton School of Nursing (M.A.D., A.S., S.M.M.), Department of Epidemiology & Biostatistics (A.S.), and School of Medicine (R.J.), Case Western Reserve University, Cleveland, OH; Department of Psychology, Oklahoma State University, Stillwater (M.A.W.H.); Department of Psychological Sciences, Kent State University, OH (J.T.S., J.G., J.W.H.); Cardiovascular Institute, Summa Health System, Akron City Hospital, OH (J.D.R., J.W.H.); and Harrington Heart & Vascular Institute, University Hospitals, Cleveland, OH (R.J.).
John GunstadFrom the Frances Payne Bolton School of Nursing (M.A.D., A.S., S.M.M.), Department of Epidemiology & Biostatistics (A.S.), and School of Medicine (R.J.), Case Western Reserve University, Cleveland, OH; Department of Psychology, Oklahoma State University, Stillwater (M.A.W.H.); Department of Psychological Sciences, Kent State University, OH (J.T.S., J.G., J.W.H.); Cardiovascular Institute, Summa Health System, Akron City Hospital, OH (J.D.R., J.W.H.); and Harrington Heart & Vascular Institute, University Hospitals, Cleveland, OH (R.J.).
Joseph D RedleFrom the Frances Payne Bolton School of Nursing (M.A.D., A.S., S.M.M.), Department of Epidemiology & Biostatistics (A.S.), and School of Medicine (R.J.), Case Western Reserve University, Cleveland, OH; Department of Psychology, Oklahoma State University, Stillwater (M.A.W.H.); Department of Psychological Sciences, Kent State University, OH (J.T.S., J.G., J.W.H.); Cardiovascular Institute, Summa Health System, Akron City Hospital, OH (J.D.R., J.W.H.); and Harrington Heart & Vascular Institute, University Hospitals, Cleveland, OH (R.J.).
Richard JosephsonFrom the Frances Payne Bolton School of Nursing (M.A.D., A.S., S.M.M.), Department of Epidemiology & Biostatistics (A.S.), and School of Medicine (R.J.), Case Western Reserve University, Cleveland, OH; Department of Psychology, Oklahoma State University, Stillwater (M.A.W.H.); Department of Psychological Sciences, Kent State University, OH (J.T.S., J.G., J.W.H.); Cardiovascular Institute, Summa Health System, Akron City Hospital, OH (J.D.R., J.W.H.); and Harrington Heart & Vascular Institute, University Hospitals, Cleveland, OH (R.J.).
Shirley M MooreFrom the Frances Payne Bolton School of Nursing (M.A.D., A.S., S.M.M.), Department of Epidemiology & Biostatistics (A.S.), and School of Medicine (R.J.), Case Western Reserve University, Cleveland, OH; Department of Psychology, Oklahoma State University, Stillwater (M.A.W.H.); Department of Psychological Sciences, Kent State University, OH (J.T.S., J.G., J.W.H.); Cardiovascular Institute, Summa Health System, Akron City Hospital, OH (J.D.R., J.W.H.); and Harrington Heart & Vascular Institute, University Hospitals, Cleveland, OH (R.J.).
Joel W HughesFrom the Frances Payne Bolton School of Nursing (M.A.D., A.S., S.M.M.), Department of Epidemiology & Biostatistics (A.S.), and School of Medicine (R.J.), Case Western Reserve University, Cleveland, OH; Department of Psychology, Oklahoma State University, Stillwater (M.A.W.H.); Department of Psychological Sciences, Kent State University, OH (J.T.S., J.G., J.W.H.); Cardiovascular Institute, Summa Health System, Akron City Hospital, OH (J.D.R., J.W.H.); and Harrington Heart & Vascular Institute, University Hospitals, Cleveland, OH (R.J.). jhughes1@kent.edu.
Oklahoma State University · USSumma Health System · USKent State University · US

Funding

Cognitive Impairment and Self-management in Adults with Heart FailureR01HL096710 · NHLBI · KENT STATE UNIVERSITY · PI DOLANSKY, MARY, HUGHES, JOEL W · 2010 to 2013
$2.7M
NHLBI NIH HHS R01 HL096710
6 · The paper itself

Abstract

backgroundSubclinical cognitive impairment is prevalent in heart failure (HF); however, its role in important clinical outcomes, such as HF treatment adherence, is unclear. Given the complex polypharmacy in HF treatment, cognitive deficits may be important in predicting medication management. Thus, the objective of the current study was to examine the impact of cognitive function on medication adherence among community-dwelling patients with HF using objective assessments. METHODS AND

resultsA prospective observational cohort design of 309 community-dwelling patients with HF (59.7% male, 68.7±9.7 years) and no history of dementia or neurological disease. Cognition was assessed using a neuropsychological battery at baseline. Medication adherence was objectively measured for 21 days using an electronic pillbox. Regression analyses tested whether attention, executive function, or memory predicted 21-day medication adherence. In unadjusted analyses, lower scores on all 3 cognitive domains predicted poorer medication adherence (β=0.52-85; P=0.001-0.009). After adjusting for demographic, clinical, and psychosocial variables, memory continued to predict medication adherence (β=0.51; P=0.008), whereas executive function (β=0.24; P=0.075) and attention were no longer a predictor (β=0.34; P=0.131).

conclusionsPoorer cognitive function, especially in regard to memory, predicted reduced medication adherence among patients with HF and no history of dementia. This effect remained after adjustment for factors known to predict adherence, such as depressed mood, social support, and disease severity level. Future studies should examine the link from cognitive impairment and medication nonadherence to clinical outcomes (eg, hospitalization and mortality). CLINICAL

trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01461629.

Indexed as

Medication AdherenceAgedAttentionCognition DisordersExecutive FunctionFemaleHeart FailureHumansMaleMemoryMiddle AgedProspective StudiesResidence CharacteristicsRisk Factorscognitive functiondementiadepressionheart failuremedication adherence

Identifiers

PMID27895069
PMCPMC5131517
OpenAlexW2557887478

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.