Evidence map›Paper›PMID 27894927›Full record

ReviewFrontiers in neuroendocrinology2017

The dynamics of GABA signaling: Revelations from the circadian pacemaker in the suprachiasmatic nucleus.

H Elliott Albers, James C Walton, Karen L Gamble, John K McNeill, Daniel L Hummer

Open access · greenAbstract readReview
In one paragraph

Review in Frontiers in neuroendocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.

  1. Systematic review of drugs that modify the circadian system's phase-shifting responses to light exposure.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Pooled it
  2. Article
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  7. Article
  8. Review
  9. Article
  10. Article
  11. Fly into tranquility: GABA's role in Drosophila sleep.Current opinion in insect science · 2024
    Review
  12. Article
  13. Astrocytic control of extracellular GABA drives circadian timekeeping in the suprachiasmatic nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Circadian Control of Glial Cell Homeodynamics.Journal of biological rhythms · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

H Elliott AlbersCenter for Behavioral Neuroscience, Atlanta, GA 30302, United States; Neuroscience Institute, Georgia State University, Atlanta, GA 30302, United States. Electronic address: biohea@gsu.edu.
James C WaltonCenter for Behavioral Neuroscience, Atlanta, GA 30302, United States; Neuroscience Institute, Georgia State University, Atlanta, GA 30302, United States.
Karen L GambleDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, United States.
John K McNeillCenter for Behavioral Neuroscience, Atlanta, GA 30302, United States; Neuroscience Institute, Georgia State University, Atlanta, GA 30302, United States.
Daniel L HummerCenter for Behavioral Neuroscience, Atlanta, GA 30302, United States; Department of Psychology, Morehouse College, Atlanta, GA 30314, United States.
Center for Neurosciences · USGeorgia State University · USUniversity of Alabama at Birmingham · US

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI W Timothy GARVEY · 2013 to 2026
$19.5M
Circadian dysfunction and neurodegenerative diseaseR01NS082413 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GAMBLE, KAREN L · 2013 to 2022
$4.6M
Communication within the Suprachiasmatic Neural Circadian NetworkR01NS078220 · NINDS · GEORGIA STATE UNIVERSITY · PI ALBERS, H. ELLIOTT · 2012 to 2016
$1.6M
PHOTIC ENTRAINMENT OF CIRCADIAN BEHAVIORSR01MH058789 · NIMH · GEORGIA STATE UNIVERSITY · PI ALBERS, ELLIOTT H · 1998 to 2006
$1.5M
Integration of photic and nonphotic signaling in the circadian pacemakerR00GM086683 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GAMBLE, KAREN L · 2009 to 2011
$740k
The roles of GABA receptor subunits in circadian rhythms in GABA responsiveness in the suprachiasmatic nucleusF32NS092545 · NINDS · GEORGIA STATE UNIVERSITY · PI WALTON, JAMES C. · 2015 to 2017
$168k
Sleep and Melatonin in Diurnal and Nocturnal RodentsF32MH012956 · NIMH · GEORGIA STATE UNIVERSITY · PI NOVAK, COLLEEN M · 2001 to 2003
$136k
Mediating effects of GRP on circadian rhythmsF32NS051183 · NINDS · VANDERBILT UNIVERSITY · PI GAMBLE, KAREN L · 2006 to 2007
$95k
Integration of photic and nonphotic signaling in the circadian pacemakerK99GM086683 · NIGMS · VANDERBILT UNIVERSITY · PI GAMBLE, KAREN L · 2009 to 2009
$70k
GIRK channel modulation of SCN excitability and circadian rhythmsF31NS084683 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HABLITZ, LAUREN M · 2014 to 2015
$48k
Photic and Nonphotic Interactions on Circadian BehaviorF31MH067420 · NIMH · GEORGIA STATE UNIVERSITY · PI GAMBLE, KAREN L · 2003 to 2004
$29k
RAPHE NUCLEI AND CIRCADIAN RHYTHMSF32NS009927 · NINDS · GEORGIA STATE UNIVERSITY · PI MINTZ, ERIC M · 1995 to 1996
–
NIDDK NIH HHS P30 DK079626NIGMS NIH HHS K99 GM086683NIGMS NIH HHS R00 GM086683NIMH NIH HHS F31 MH067420NIMH NIH HHS F32 MH012956NIMH NIH HHS R01 MH058789NINDS NIH HHS F31 NS084683NINDS NIH HHS F32 NS009927NINDS NIH HHS F32 NS051183NINDS NIH HHS F32 NS092545NINDS NIH HHS R01 NS078220NINDS NIH HHS R01 NS082413
6 · The paper itself

Abstract

Virtually every neuron within the suprachiasmatic nucleus (SCN) communicates via GABAergic signaling. The extracellular levels of GABA within the SCN are determined by a complex interaction of synthesis and transport, as well as synaptic and non-synaptic release. The response to GABA is mediated by GABA

Indexed as

AnimalsBiological ClocksCircadian Rhythmgamma-Aminobutyric AcidHumansSignal TransductionSuprachiasmatic Nucleusgamma-Aminobutyric AcidBenzodiazepinesCation chloride cotransportersEntrainmentEthanolGABA(A) receptorsGABA(B) receptorsGABA vesicular transportersGlutamic acid decarboxylaseMembrane GABA transportersNeurosteroids

Identifiers

PMID27894927
PMCPMC5225159
OpenAlexW2553469214

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.