ArticleJournal of biomechanics2017
A multiscale biomechanical model of platelets: Correlating with in-vitro results.
Article in Journal of biomechanics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Neosinus and Valve Thrombosis After Transcatheter Aortic Valve Replacement.Journal of the American Heart Association · 2026Pooled it
- Article
- The Effect of von Willebrand Disease on Platelet Adhesion Dynamics: Correlating a Multiscale Platelet Model to In Vitro Results.IEEE transactions on bio-medical engineering · 2026Article
- In silico biophysics and rheology of blood and red blood cells in Gaucher Disease.PLoS computational biology · 2025Article
- A Biophysics-Based Mathematical Model of Shear-Induced Platelet Activation and Receptor Shedding: Re-Examining Previous Experimental Data.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2025Article
- In silico biophysics and rheology of blood and red blood cells in Gaucher Disease.bioRxiv : the preprint server for biology · 2024Article
- Red blood cell passage through deformable interendothelial slits in the spleen: Insights into splenic filtration and hemodynamics.Computers in biology and medicine · 2024Article
- Platelet Biorheology and Mechanobiology in Thrombosis and Hemostasis: Perspectives from Multiscale Computation.International journal of molecular sciences · 2024Review
- Vibro-Acoustic Platelet Activation: An Additive Mechanism of Prothrombosis with Applicability to Snoring and Obstructive Sleep Apnea.Bioengineering (Basel, Switzerland) · 2023Article
- A combined computational and experimental investigation of the filtration function of splenic macrophages in sickle cell disease.PLoS computational biology · 2023Article
- In silico and in vitro study of the adhesion dynamics of erythrophagocytosis in sickle cell disease.Biophysical journal · 2023Article
- A Multiscale Model for Shear-Mediated Platelet Adhesion Dynamics: Correlating In Silico with In Vitro Results.Annals of biomedical engineering · 2023Article
- Shear-Mediated Platelet Microparticles Demonstrate Phenotypic Heterogeneity as to Morphology, Receptor Distribution, and Hemostatic Function.International journal of molecular sciences · 2023Article
- Article
- A prestressed intracellular biomechanical model for the platelet to capture the disc-to-sphere morphological change from resting to activated state.International journal of computational methods · 2022Article
- Circulating cell clusters aggravate the hemorheological abnormalities in COVID-19.Biophysical journal · 2022Article
- Models of Shear-Induced Platelet Activation and Numerical Implementation With Computational Fluid Dynamics Approaches.Journal of biomechanical engineering · 2022Article
- Multiphysics and multiscale modeling of microthrombosis in COVID-19.PLoS computational biology · 2022Article
- Mathematical and Computational Modeling of Device-Induced Thrombosis.Current opinion in biomedical engineering · 2021Article
- In Vitro Measurements of Shear-Mediated Platelet Adhesion Kinematics as Analyzed through Machine Learning.Annals of biomedical engineering · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Using dissipative particle dynamics (DPD) combined with coarse grained molecular dynamics (CGMD) approaches, we developed a multiscale deformable platelet model to accurately describe the molecular-scale intra-platelet constituents and biomechanical properties of platelets in blood flow. Our model includes the platelet bilayer membrane, cytoplasm and an elaborate elastic cytoskeleton. Correlating numerical simulations with published in-vitro experiments, we validated the biorheology of the cytoplasm, the elastic response of membrane to external stresses, and the stiffness of the cytoskeleton actin filaments, resulting in an accurate representation of the molecular-level biomechanical microstructures of platelets. This enabled us to study the mechanotransduction process of the hemodynamic stresses acting onto the platelet membrane and transmitted to these intracellular constituents. The platelets constituents continuously deform in response to the flow induced stresses. To the best of our knowledge, this is the first molecular-scale platelet model that can be used to accurately predict platelets activation mechanism leading to thrombus formation in prosthetic cardiovascular devices and in vascular disease processes. This model can be further employed to study the effects of novel therapeutic approaches of modulating platelet properties to enhance their shear resistance via mechanotransduction pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.