ArticleeLife2016
Discovery of methylfarnesoate as the annelid brain hormone reveals an ancient role of sesquiterpenoids in reproduction.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Molecular evidence for early deuterostome origins of ovarian cell types and neuroendocrine control of reproduction.Nature communications · 2026Article
- Photoreceptor control ofProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Macrophage-mediated nutrient recycling: evolutionary insights into the metabolic role of professional phagocytes.Frontiers in immunology · 2026Review
- Sesquiterpenoid Hormones Farnesoic Acid and Methyl Farnesoate Regulate Different Gene Sets in ShrimpBiomolecules · 2025Article
- Sex-specific differential gene expression during stolonization in the branching syllid Ramisyllis kingghidorahi (Annelida, Syllidae).BMC genomics · 2025Article
- Developmental stage dependent effects of posterior and germline regeneration on sexual maturation in Platynereis dumerilii.Developmental biology · 2024Article
- Annelids as models of germ cell and gonad regeneration.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Review
- Annelid adult cell type diversity and their pluripotent cellular origins.Nature communications · 2024Article
- The cost and payout of age on germline regeneration and sexual maturation inbioRxiv : the preprint server for biology · 2024Article
- Morphological, histological and gene-expression analyses on stolonization in the Japanese Green Syllid, Megasyllis nipponica (Annelida, Syllidae).Scientific reports · 2023Article
- Cell Proliferation Indices in RegeneratingCells · 2023Article
- Remodeling of theBiology · 2023Article
- Segment number threshold determines juvenile onset of germline cluster expansion in Platynereis dumerilii.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2022Article
- Rethinking Sesquiterpenoids: A Widespread Hormone in Animals.International journal of molecular sciences · 2022Article
- Genome of the ramshorn snail Biomphalaria straminea-an obligate intermediate host of schistosomiasis.GigaScience · 2022Article
- A pan-metazoan concept for adult stem cells: the wobbling Penrose landscape.Biological reviews of the Cambridge Philosophical Society · 2022Article
- Articulating the "stem cell niche" paradigm through the lens of non-model aquatic invertebrates.BMC biology · 2022Review
- Neural regulation of body polarities in nereid worm regeneration.FASEB bioAdvances · 2022Article
- The Nereid on the rise: Platynereis as a model system.EvoDevo · 2021Review
- Comparative Aspects of Annelid Regeneration: Towards Understanding the Mechanisms of Regeneration.Genes · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Animals require molecular signals to determine when to divert resources from somatic functions to reproduction. This decision is vital in animals that reproduce in an all-or-nothing mode, such as bristle worms: females committed to reproduction spend roughly half their body mass for yolk and egg production; following mass spawning, the parents die. An enigmatic brain hormone activity suppresses reproduction. We now identify this hormone as the sesquiterpenoid methylfarnesoate. Methylfarnesoate suppresses transcript levels of the yolk precursor Vitellogenin both in cell culture and
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.