Evidence map›Paper›PMID 27894312›Full record

ArticleJournal of nanobiotechnology2016

Release of copper-amended particles from micronized copper-pressure-treated wood during mechanical abrasion.

Chiara Civardi, Lukas Schlagenhauf, Jean-Pierre Kaiser, Cordula Hirsch, Claudio Mucchino, Adrian Wichser, Peter Wick, Francis W M R Schwarze

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Chiara CivardiLaboratory for Applied Wood Materials, Empa, Lerchenfeldstrasse 5, 9014, St. Gallen, Switzerland. civardic@student.ethz.ch.ORCID http://orcid.org/0000-0001-5741-2610
Lukas SchlagenhaufEmpa, Functional Polymers, Dübendorf, Switzerland.
Jean-Pierre KaiserParticles-Biology Interactions, Empa, St. Gallen, Switzerland.
Cordula HirschParticles-Biology Interactions, Empa, St. Gallen, Switzerland.
Claudio MucchinoDipartimento di Chimica, Università degli Studi di Parma, Parma, Italy.
Adrian WichserEmpa, Analytical Chemistry, Dübendorf, Switzerland.
Peter WickParticles-Biology Interactions, Empa, St. Gallen, Switzerland.
Francis W M R SchwarzeLaboratory for Applied Wood Materials, Empa, Lerchenfeldstrasse 5, 9014, St. Gallen, Switzerland. francis.schwarze@empa.ch.
University of St.Gallen · CHETH Zurich · CHInstitute for Biomedical Engineering · CHSwiss Federal Laboratories for Materials Science and Technology · CHUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe investigated the particles released due to abrasion of wood surfaces pressure-treated with micronized copper azole (MCA) wood preservative and we gathered preliminary data on its in vitro cytotoxicity for lung cells. The data were compared with particles released after abrasion of untreated, water (0% MCA)-pressure-treated, chromated copper (CC)-pressure-treated wood, and varnished wood. Size, morphology, and composition of the released particles were analyzed.

resultsOur results indicate that the abrasion of MCA-pressure-treated wood does not cause an additional release of nanoparticles from the unreacted copper (Cu) carbonate nanoparticles from of the MCA formulation. However, a small amount of released Cu was detected in the nanosized fraction of wood dust, which could penetrate the deep lungs. The acute cytotoxicity studies were performed on a human lung epithelial cell line and human macrophages derived from a monocytic cell line. These cell types are likely to encounter the released wood particles after inhalation.

conclusionsOur findings indicate that under the experimental conditions chosen, MCA does not pose a specific additional nano-risk, i.e. there is no additional release of nanoparticles and no specific nano-toxicity for lung epithelial cells and macrophages.

Indexed as

A549 CellsCell LineCell SurvivalCopperHumansMass SpectrometryNanoparticlesPressureReactive Oxygen SpeciesWaterWoodCopperReactive Oxygen SpeciesWaterCopper particlesCytotoxicityDebrisExposureInhalationWood dust

Identifiers

PMID27894312
PMCPMC5126862
OpenAlexW2557468077

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.