Evidence map›Paper›PMID 27894284›Full record

ArticleBMC musculoskeletal disorders2016

Proarrhythmic risk and determinants of cardiac autonomic dysfunction in collagen-induced arthritis rats.

Ting-Tse Lin, Yen-Ling Sung, Chih-En Wu, Hong Zhang, Yen-Bin Liu, Shien-Fong Lin

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Article in BMC musculoskeletal disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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5 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Ting-Tse LinDepartment of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.
Yen-Ling SungInstitute of Biomedical Engineering, National Chiao-Tung University, 1001 Ta-Hsueh Road, Hsinchu, 300, Taiwan.
Chih-En WuInstitute of Biomedical Engineering, National Chiao-Tung University, 1001 Ta-Hsueh Road, Hsinchu, 300, Taiwan.
Hong ZhangDepartment of Electrical Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Yen-Bin LiuDepartment of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.
Shien-Fong LinInstitute of Biomedical Engineering, National Chiao-Tung University, 1001 Ta-Hsueh Road, Hsinchu, 300, Taiwan. linsf5402@nctu.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundsPatients with rheumatoid arthritis (RA) have increased risk of sudden cardiac death (SCD), which is two-fold higher than general population. The driving cause of SCD was considered due to lift-threatening arrhythmia where systemic inflammation acts as the pathophysiological basis linking RA to autonomicdysfunction.

methodsTo assess the sympathetic over-activity of "inflammatory reflex", we measured heart rate variability (HRV) in a rat collagen-induced arthritis (CIA) model, whose arthritis is induced in Lewis rats by intradermal injection of emulsion of type II collagen. Single-lead electrocardiogram (ECG) was recorded for 30 min every two days. Time and frequency-domain parameters, detrended fluctuation analysis (DFA), deceleration (DC) and acceleration capacity (AC) were analyzed.

resultsCompared with 9 control rats, many of HRV parameters of 9 CIA rats revealed significant different. At the beginning of arthritis, LF/HF was significant higher than controls (1st week: 2.41 ± 0.7 vs. 1.76 ± 0.6, p < 0.05; 2nd week: 2.24 ± 0.5 vs. 1.58 ± 0.5, p < 0.05) indicating intensive inflammatory reflex at the initial phase of inflammation but no significant difference was observed in the following recover phase. The similar trend of DFA parameters was noted. However, the DC appeared progressive lower despite of no significant increase of the LF/HF compared with controls since 4th week.

conclusionsWe observed sympathetic over-activation of inflammatory reflex during early stage of arthritis in CIA rats. The ongoing decline of DC indicated advanced cardiac autonomic dysfunction regardless of remission of acute arthritis.

Indexed as

AnimalsArrhythmias, CardiacArthritis, ExperimentalArthritis, RheumatoidAutonomic Nervous System DiseasesCollagen Type IIElectrocardiographyHeart RateHumansRatsRats, Inbred LewRiskCollagen Type IIAutonomic functionCollagen-induced arthritisDeceleration capacityHeart rate variabilityRheumatoid arthritis

Identifiers

PMID27894284
PMCPMC5127040

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.