ArticleBMC genomics2016
Latitudinal clines in gene expression and cis-regulatory element variation in Drosophila melanogaster.
Article in BMC genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- An Epigenetic Clock for Accurate Age Prediction in Atlantic Cod Populations for Improved Fisheries Management.Molecular ecology resources · 2026Article
- Phylogenetic Relatedness Does not Predict Patterns of Parallel Transcriptome Adaptation in Drosophila.Genome biology and evolution · 2025Article
- The regulatory architecture of gene expression variation in Caenorhabditis elegans revealed by multi-strain allele-specific analysis.Genetics · 2025Article
- Divergence and Parallelism in Two Tropical Drosophilids Simultaneously Invading a Desert Environment.Genome biology and evolution · 2025Article
- The regulatory architecture of gene expression variation inbioRxiv : the preprint server for biology · 2025Article
- Across two continents: The genomic basis of environmental adaptation in house mice (Mus musculus domesticus) from the Americas.PLoS genetics · 2024Article
- Across two continents: the genomic basis of environmental adaptation in house mice (bioRxiv : the preprint server for biology · 2023Article
- Impact of Heat Stress on Transposable Element Expression and Derived Small RNAs in Drosophila subobscura.Genome biology and evolution · 2023Article
- Selection and geography shape male reproductive tract transcriptomes in Drosophila melanogaster.Genetics · 2023Article
- Distinct signals of clinal and seasonal allele frequency change at eQTLs in Drosophila melanogaster.Evolution; international journal of organic evolution · 2022Article
- Shedding Light on Inter-Individual Variability of Olfactory Circuits inFrontiers in behavioral neuroscience · 2022Review
- Regulatory regions in natural transposable element insertions drive interindividual differences in response to immune challenges in Drosophila.Genome biology · 2021Article
- Parallel and population-specific gene regulatory evolution in cold-adapted fly populations.Genetics · 2021Article
- The mode of expression divergence inGenome research · 2021Article
- Behavior Individuality: A Focus onFrontiers in physiology · 2021Review
- Contributions of cis- and trans-Regulatory Evolution to Transcriptomic Divergence across Populations in the Drosophila mojavensis Larval Brain.Genome biology and evolution · 2020Article
- Transcriptome analysis ofEcology and evolution · 2020Article
- Population Genetic and Functional Analysis of aGenes · 2019Article
- Genome-wide patterns of local adaptation in Western European Drosophila melanogaster natural populations.Scientific reports · 2018Article
- Genetic variation for tolerance to high temperatures in a population ofEcology and evolution · 2018Article
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Authors and funding
3 authors.
Funding
Abstract
backgroundOrganisms can rapidly adapt to their environment when colonizing a new habitat, and this could occur by changing protein sequences or by altering patterns of gene expression. The importance of gene expression in driving local adaptation is increasingly being appreciated, and cis-regulatory elements (CREs), which control and modify the expression of the nearby genes, are predicted to play an important role. Here we investigate genetic variation in gene expression in immune-challenged Drosophila melanogaster from temperate and tropical or sub-tropical populations in Australia and United States.
resultsWe find parallel latitudinal changes in gene expression, with genes involved in immunity, insecticide resistance, reproduction, and the response to the environment being especially likely to differ between latitudes. By measuring allele-specific gene expression (ASE), we show that cis-regulatory variation also shows parallel latitudinal differences between the two continents and contributes to the latitudinal differences in gene expression.
conclusionsBoth Australia and United States were relatively recently colonized by D. melanogaster, and it was recently shown that introductions of both African and European flies occurred, with African genotypes contributing disproportionately to tropical populations. Therefore, both the demographic history of the populations and local adaptation may be causing the patterns that we see.
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