ArticleAddiction biology2018
Cue-induced nicotine-seeking behavior after withdrawal with or without extinction in rats.
Article in Addiction biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Early life nicotine vapor exposure increases nicotine vapor seeking in adult male rats.Psychopharmacology · 2026Article
- Extinction of Nicotine and Cocaine Seeking in Rats Reveals Novel, Unique and Time-Dependent Molecular Adaptations in the Medial Prefrontal Cortex.Cellular and molecular neurobiology · 2026Article
- Article
- Dopamine and Norepinephrine Tissue Levels in the Developing Limbic Brain Are Impacted by the HumanInternational journal of molecular sciences · 2024Article
- Memory consolidation drives the enhancement of remote cocaine memory via prefrontal circuit.Molecular psychiatry · 2024Article
- Sex differences in nicotine intake and relapse behavior in nicotine-dependent adult wistar rats.Frontiers in pharmacology · 2024Article
- Article
- Effects of heroin self-administration and forced withdrawal on the expression of genes related to the mTOR network in the basolateral complex of the amygdala of male Lewis rats.Psychopharmacology · 2022Article
- Relapse-like behavior and nAChR sensitization following intermittent access nicotine self-administration.Neuropharmacology · 2022Article
- Assessing combined effects of varenicline and N-acetylcysteine on reducing nicotine seeking in rats.Addiction biology · 2022Article
- Incubation of alcohol craving as it naturally occurs in a developmentally diverse sample of dependent and nondependent drinkers.Addiction biology · 2021Article
- Self-Administration of Toluene Vapor in Rats.Frontiers in neuroscience · 2020Article
- Effects of Framing Nicotine Reduction in Cigarettes on Anticipated Tobacco Product Use Intentions and Risk Perceptions Among US Adult Smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Article
- Detrimental Effects of a Retrieval-Extinction Procedure on Nicotine Seeking, but Not Cocaine Seeking.Frontiers in behavioral neuroscience · 2019Article
- Metabotropic Glutamate Receptors 2 and 3 as Targets for Treating Nicotine Addiction.Biological psychiatry · 2018Review
- Kinase interest you in treating incubated cocaine-craving? A hypothetical model for treatment intervention during protracted withdrawal from cocaine.Genes, brain, and behavior · 2018Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Exposure to smoking-associated environmental cues during smoke cessation elicits self-reported urge/craving to smoke, which precipitates relapse even after prolonged abstinence. Incubation of cue-induced cigarettes craving during abstinence has been observed in human smokers recently. The present studies assessed cue-induced nicotine-seeking behavior under different withdrawal conditions in rats with a history of nicotine self-administration. We found that non-reinforced operant responding during cue-induced nicotine seeking after different periods of withdrawal from nicotine exhibited an inverted U-shaped curve, with higher levels of responding after 7-21 days of withdrawal than those after 1-day withdrawal. Cue-induced nicotine-seeking responding is long lasting and persists even after 42 days of forced withdrawal in the home cages. Interestingly, repeated testing of cue-induced nicotine seeking at different withdrawal time points (1, 7, 14, 21 and 42 days) in the same individual alleviated responding as compared with the between-subjects assessment. Furthermore, extinction training during nicotine withdrawal significantly decreased cue-induced reinstatement of nicotine-seeking behavior. Together, profound time-dependent incubation of cue-induced craving in nicotine-experienced rats were observed. In addition, repeated cue exposure or extinction training decreases cue-induced craving. The demonstration of incubation of nicotine craving phenomenon in both rat and human studies provides support for the translational potential of therapeutic targets for relapse uncovered through mechanism studies in rats.
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