ArticleOncotarget2016
Genetic variants in the acylphosphatase 2 gene and the risk of breast cancer in a Han Chinese population.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations between polymorphisms of the ACYP2 gene and Liver cancer risk: A case-control study and meta-analysis.Molecular genetics & genomic medicine · 2019Pooled it
- The role of genetic variants in the prediction of hearing loss due to cisplatin chemoradiotherapy.Cancer medicine · 2024Article
- Skin single-cell transcriptomics reveals a core of sebaceous gland-relevant genes shared by mice and humans.BMC genomics · 2024Article
- Single nucleotide polymorphisms in telomere length-related genes are associated with hepatocellular carcinoma risk in the Chinese Han population.Therapeutic advances in medical oncology · 2020Article
- ADAMTS8 Inhibits Cell Proliferation and Invasion, and Induces Apoptosis in Breast Cancer.OncoTargets and therapy · 2020Article
- Association between ACYP2 polymorphisms and the risk of renal cell cancer.Molecular genetics & genomic medicine · 2019Article
- Genetic and Modifiable Risk Factors Contributing to Cisplatin-induced Toxicities.Clinical cancer research : an official journal of the American Association for Cancer Research · 2019Review
- Association ofOncotarget · 2017Article
- Article
- Association analysis of telomere length related gene ACYP2 with the gastric cancer risk in the northwest Chinese Han population.Oncotarget · 2017Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
We performed a case-control study to investigate the associations between seven single nucleotide polymorphisms (SNPs) in the acylphosphatase 2 (ACYP2) gene and breast cancer (BC) risk in a Han Chinese population. There were 183 BC cases and 195 healthy controls included in the study. The SNPs were genotyped using the Sequenom MassARRAY platform. Logistic regression (adjusted for age group, body mass index [BMI], and menopause status), was used to evaluate the associations between the various genotypes and BC risk. Statistical analysis revealed that rs12621038 was associated with a decreased risk of BC in the allele (T vs. C: odds ratio [OR] = 0.71, 95% confidence interval [95% CI] = 0.52-0.94; p = 0.016), homozygous (TT vs. CC: OR = 0.47, 95% CI = 0.24-0.85; p = 0.014), dominant (OR = 0.62; 95% CI = 0.40-0.96; p = 0.032), and additive (OR = 0.68; 95% CI = 0.50-0.92; p = 0.012) models. In addition, we found that rs1682111 and rs17045754 were associated with the risk of BC and correlated with recurrence, and that rs6713088 correlated with tumor size. In sum, our findings reveal significant associations between SNPs in the ACYP2 gene and BC risk in a Han Chinese population.
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