Evidence map›Paper›PMID 27894063›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2017

Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation.

Khanh Pham, Jie Dong, Xiqian Jiang, Ying Qu, Han Yu, Yisheng Yang, Walter Olea, Juan C Marini, Lawrence Chan, Jin Wang and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Hydrogen Peroxide and Redox Regulation of Developments.Antioxidants (Basel, Switzerland) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Khanh PhamUSDA/ARS Children Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Jie DongLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.
Xiqian JiangDepartment of Pharmacology, Baylor College of Medicine, Houston, Texas.
Ying QuDepartment of Surgery, Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, California.
Han YuUSDA/ARS Children Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Yisheng YangDepartment of Medicine, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio.
Walter OleaUSDA/ARS Children Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Juan C MariniSection of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Lawrence ChanDepartment of Medicine, Baylor College of Medicine, Houston, Texas.
Jin WangDepartment of Pharmacology, Baylor College of Medicine, Houston, Texas.
Xander H T WehrensUSDA/ARS Children Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Xiaojiang CuiDepartment of Surgery, Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, California.
Yi LiLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.
Darryl L HadsellUSDA/ARS Children Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Ninghui ChengUSDA/ARS Children Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas; ncheng@bcm.edu.
Baylor College of Medicine · USChildren's Nutrition Research Center at Baylor College of Medicine · USCedars-Sinai Medical Center · USMetroHealth Medical Center · US

Funding

Ryanodine receptor regulation in post-operative atrial fibrillationR01HL089598 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2007 to 2022
$6.5M
The Role of FOXCI in Basal-like Breast CancerR01CA151610 · NCI · SAINT JOHN'S CANCER INSTITUTE · PI CUI, XIAOJIANG · 2011 to 2022
$3.8M
Regulation of Sarcoplasmic Reticulum Calcium Release in Heart FailureR01HL091947 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2009 to 2019
$3.2M
Determining the Role of Junctophilin-2 in Cardiac DiseaseR01HL117641 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2014 to 2017
$2.3M
REAL-TIME QUANTITATIVE IMAGING OF INTRACELLULAR BIOTHIOL DYNAMICSR01GM115622 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI WANG, JIN · 2015 to 2019
$1.6M
Development of novel compounds for the treatment of atrial fibrillationR41HL129570 · NHLBI · ELEX BIOTECH, LLC · PI WEHRENS, XANDER H.T. · 2015 to 2015
$428k
NCI NIH HHS R01 CA151610NHLBI NIH HHS R01 HL089598NHLBI NIH HHS R01 HL091947NHLBI NIH HHS R01 HL117641NHLBI NIH HHS R41 HL129570NIGMS NIH HHS R01 GM115622
6 · The paper itself

Abstract

Mammalian glutaredoxin 3 (Grx3) has been shown to be important for regulating cellular redox homeostasis in the cell. Our previous studies indicate that Grx3 is significantly overexpressed in various human cancers including breast cancer and demonstrate that Grx3 controls cancer cell growth and invasion by regulating reactive oxygen species (ROS) and NF-κB signaling pathways. However, it remains to be determined whether Grx3 is required for normal mammary gland development and how it contributes to epithelial cell proliferation and differentiation in vivo. In the present study, we examined Grx3 expression in different cell types within the developing mouse mammary gland (MG) and found enhanced expression of

Indexed as

AnimalsBlotting, WesternCell ProliferationCyclin D1Epithelial CellsFemaleGene Expression Regulation, DevelopmentalGlutaredoxinsImmunohistochemistryLactationMammary Glands, AnimalMiceMice, KnockoutMilk ProteinsNF-kappa BPregnancyCcnd1 protein, mouseCyclin D1GlutaredoxinsMilk ProteinsNF-kappa BRANK LigandReactive Oxygen SpeciesReceptor Activator of Nuclear Factor-kappa BReceptors, ProgesteroneRNA, MessengerTnfrsf11a protein, mouseTnfsf11 protein, mousealveologenesisbreast cancerglutaredoxinmammary epithelial cellsmammary gland

Identifiers

PMID27894063
PMCPMC5374299
OpenAlexW2553369547

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.