Evidence map›Paper›PMID 27893987›Full record

ReviewTranslational research : the journal of laboratory and clinical medicine2017

Transdisciplinary approaches enhance the production of translational knowledge.

Timothy H Ciesielski, Melinda C Aldrich, Carmen J Marsit, Robert A Hiatt, Scott M Williams

Abstract readReview
In one paragraph

Review in Translational research : the journal of laboratory and clinical medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  14. What is One Health?The Canadian veterinary journal = La revue veterinaire canadienne · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Timothy H CiesielskiInstitute for Quantitative Biomedical Sciences, Dartmouth College, Hanover, NH; Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH; Public Health Program, Regis College, Weston, Mass. Electronic address: timothyhciesielski@gmail.com.
Melinda C AldrichDepartment of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, Tenn; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn.
Carmen J MarsitDepartment of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, NH; Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH.
Robert A HiattDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, Calif.
Scott M WilliamsInstitute for Quantitative Biomedical Sciences, Dartmouth College, Hanover, NH; Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH.

Funding

Quantitative Biology Research InstituteP20GM103534 · NIGMS · DARTMOUTH COLLEGE · PI AMOS, CHRISTOPHER I. · 2012 to 2016
$8.6M
Environment, Imprinting, and NeurodevelopmentR01ES022223 · NIEHS · EMORY UNIVERSITY · PI CHEN, JIA, MARSIT, CARMEN JOSEPH · 2013 to 2017
$4.3M
Meeting AccountU01ES019457 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HIATT, ROBERT A · 2010 to 2014
$3.2M
Epigenetics in Neurodevelopment and Mental HealthR01MH094609 · NIMH · DARTMOUTH COLLEGE · PI MARSIT, CARMEN JOSEPH · 2011 to 2015
$2.3M
Unraveling Genetic Determinants of Lung Cancer Risk in African AmericansK07CA172294 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALDRICH, MELINDA · 2013 to 2017
$801k
NCI NIH HHS K07 CA172294NIEHS NIH HHS R01 ES022223NIEHS NIH HHS U01 ES019457NIGMS NIH HHS P20 GM103534NIMH NIH HHS R01 MH094609
6 · The paper itself

Abstract

The primary goal of translational research is to generate and apply knowledge that can improve human health. Although research conducted within the confines of a single discipline has helped us to achieve this goal in many settings, this unidisciplinary approach may not be optimal when disease causation is complex and health decisions are pressing. To address these issues, we suggest that transdisciplinary approaches can facilitate the progress of translational research, and we review publications that demonstrate what these approaches can look like. These examples serve to (1) demonstrate why transdisciplinary research is useful, and (2) stimulate a conversation about how it can be further promoted. While we note that open-minded communication is a prerequisite for germinating any transdisciplinary work and that epidemiologists can play a key role in promoting it, we do not propose a rigid protocol for conducting transdisciplinary research, as one really does not exist. These achievements were developed in settings where typical disciplinary and institutional barriers were surmountable, but they were not accomplished with a single predetermined plan. The benefits of cross-disciplinary communication are hard to predict a priori and a detailed research protocol or process may impede the realization of novel and important insights. Overall, these examples demonstrate that enhanced cross-disciplinary information exchange can serve as a starting point that helps researchers frame better questions, integrate more relevant evidence, and advance translational knowledge more effectively. Specifically, we discuss examples where transdisciplinary approaches are helping us to better explore, assess, and intervene to improve human health.

Indexed as

Interdisciplinary CommunicationTranslational Research, BiomedicalAnimalsDecision MakingEpidemiologistsHumansModels, Biological

Identifiers

PMID27893987
PMCPMC5362296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.